Exploration of the constituents of rubber for medicinal application is very limited due to the concern of allergenicity. However, the recent discovery of the ability of latex sera to exert specific antiproliferative activity against cancer-origin cell lines has paved a light of utilising rubber latex as therapeutics. Rubber latex and its seed oil show many potentials in various biological activities such as antifungal, antioxidant, anti-melanogenesis as well as a biomaterial in relation to angiogenesis. This review describes the current scientifically reported progress on the potential use of rubber in the field of medical research plus positive side concerning latex allergenicity.