1-azabicyclo[2.2.2]octan-3-one. HCl (1) reacts with ylidene nitrile through photo- thermal reaction conditions to give 4-benzyl-5-imino-3-phenyl-6-oxa-1-aza-tricyclo[6.2.2.02,7]dodec-2(7)-ene-4-carbonitrile. (3) via intermolecular double Micheal reaction, whereas, 5-imino-3-phenyl-6-oxa-1-azatricyclo[6.2.2.02,7]dodec-2(7)-ene-4-carbonitrile (4) was achieved via thermal conditions only.

Annulations of 2‐imino‐4‐thiazolidinone (5) via cycloaddition followed by cyclocondensation reaction with 1,3‐diphenylpropenone (6), benzylidenemalonate, and 1,2‐bis(chloromethyl)benzene gave 7, 19 and 20, respectively. Reaction of 5 with suitable electrophiles (Mannich bases of arylalkanone), 1,4‐dichlorobenzene (diarylmethylation), and formylation afforded 8/9, 21/22, and 23, respectively. J. Heterocyclic Chem., (2011).

Behavior of 2-Iminothiazolidin-4-one with Different Reagents. -With a view to obtaining biologically active derivatives the title compound (I) is annulated to suitable electrophiles via cyclocondensation reactions. -(HAMAMA*, W. S.; ISMAIL, M. A.; SOLIMAN, M.; SHAABAN, S.; ZOOROB, H. H.; J. Heterocycl. Chem. 48 (2011) 5, 1169-1174, http://dx.doi.org/10.1002/jhet.628 ; Dep. Chem., Fac. Sci., Mansoura Univ., Mansoura, Egypt; Eng.) -G. Mueller 08-030

Pyridine derivatives with bridges R 0460 Intermolecular Double Michael Reaction to Construct 4-Benzyl-5-imino-3-phenyl-6-oxa-1-aza-tricyclo[6.2.2.0 2,7 ]dodec-2(7)-ene-4-carbonitrile. -The different behavior of the quinuclidine derivative (I) is explained on the basis of MO calculations. -(ZOOROB, H. H.; HAMAMA*, W. S.; EL-MAGID, O. M. A.; SOLIMAN, M. S.; J. Chem. Res. 2005, 10, 669-672; Dep. Chem., Fac. Sci., Mansoura Univ., Mansoura, Egypt; Eng.) -H. Haber 09-161