The current case study is based on semi structured interviews. The psychological effects of stress can impair the students' ability to think, behavior and emotions during exams. Also stress can cause restlessness; lack of motivation and irritability, the research tested the effects of examination anxiety on 200 male and female high school students with effects on cardiac rhythm and vascular regulations with using a Hamilton Anxiety Scale questionnaire. The results showed a statistically significant difference (p<0.05) in groups' systolic blood pressure during the test compared to both participants after the examination. The experiment aimed at knowing the impact of anxiety/stress on the cardiovascular system, for example, blood pressure, random blood sugar and pulse levels during and after exam on high school students and their sexual predominance. This condition negatively impacts their motivation and academic performance, minimizes their interest in education, and leads to the incidence of anxiety in both academia and the family. This depression can have a destructive impact on students' professional and personal lives, leaving them anxious, exhaustive and socially isolated at low academic levels, blood pressure. The hazardous factors that can alter the arterial pressure and cardiac frequency include age, gender, ethnicity, family history, obesity, smoking and alcoholism.