Background: Asia has greatest growth rate for number of chronic diseases and end-stage organ failure, but has the lowest rate of organ transplant, particularly deceased donor. This survey was conducted to assess knowledge, awareness, and attitude regarding deceased organ-tissue donation among health care professionals (HCP) in Bangladesh. Methods: This was a cross-sectional observational study, done in six tertiary hospitals of Dhaka from January to June 2022. A questionnaire constructed by the Asian Society of Transplantation was used for data collection. Statistical analysis was performed by SAS software. Results: A total of 446 HCP participated. There were nurses (42.0%), medical students (29.0%), doctors (21.0%), and others (8.0%). The mean age of participants was 28 years; 44.0% were male participants and 56.0% were female. About 92.6% participants heard about organ-tissue donation, but majority (75.2%) never participated in educational programs and only 8.3% knew it well. About 72.3% HCP showed positive attitude towards organ-tissue donation. Nonetheless, 24.0% strongly wished to donate and only 0.9% registered as donor. The main reason for not willing to donate were never thought about it (29.0%) and lack of information (27.0%). The principle cause of not registering was not knowing the procedure (34.4%). Majority advised outdoor campaigns, educational activities, and TV commercials as necessary sources for activating brain death donation. However, most reliable source for information chosen was TV (53.7%), Internet, and newspaper. Majority felt that when promoting life-sharing, the essential message that should be delivered is giving new lives to patients. About 85.0% participants knew the difference between brainstem death and vegetative state, 75.0% considered brain death as death and 46.4% assumed one brain death donor can save five persons lives. Conclusions: There was lack of knowledge, awareness, and attitude about deceased organ-tissue donation among HCP in Bangladesh. More educational program is needed to improve deceased organ transplantation.
Infections are common complications in kidney transplant recipients owing to the lifelong immunosuppression. Cytomegalovirus (CMV) and varicella zoster virus (VZV) infections are quite common in the posttransplant period. Coinfection with both however has been reported only once. The immunomodulatory effect of CMV makes their interaction with other organisms like VZV potentially sinister. This is a case of a female who developed coinfection with HZV and CMV in the first month following a live related kidney transplantation. A 32-year-old female, with a presumptive diagnosis of glomerulonephritis, hypertension and chronic kidney (CKD) underwent live-related kidney transplantation from her mother following a period of hemodialysis for 8 months. There was one haplotype match and both B and T cell cross matches were negative. CMV DNA was undetected in both donor and recipient prior to transplantation. Immunosuppression consisted of prednisolone, mycophenolate sodium and tacrolimus. The surgery went well, yielding a urine output of 4-6 L/day. However, the serum creatinine did not reach baseline, with a nadir of 2 mg/dL. On the postoperative day (POD) 25, she developed low grade fever, which was followed 2 days later by pain and vesicular eruptions involving the dermatomal distribution of the ophthalmic division of the trigeminal nerve (V1) on the left, resembling herpes zoster ophthalmicus. CMV polymerase chain reaction (PCR) yielded 300 copies/mL. Treatment was immediately started with oral Acyclovir, which was later switched to oral Ganciclovir, along with acyclovir ointment and ganciclovir eye gel. The patient's fever subsided and the skin lesions resolved over a period of 2 weeks. Serum creatinine came down to baseline. Infections after kidney transplant is often difficult to diagnose, manage and cure, especially in the immediate posttransplant period. In our case, early diagnosis and treatment resulted in a good outcome.
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