Organophosphorus insecticides have been widely classified as a health dangerous and high toxicity compounds due to their widespread use and release into the environment. Ginger (Zingiber officinale) has been used as a medicinal plant since antiquity and is known to play diverse biological roles including anti oxidation, anti-inflammation, hyperlipidemia, anti-carcinogenesis, anti-nausea, anti-thrombosis, and antibacterial process. The purpose of these experiments was to study decreasing the toxicity effect of Dimethoate by ginger. All animals in this study were assigned to one of four treatment groups: 0 mg ginger and 0 mg dimethoate /kg BW (control); 100 mg ginger/kg BW; 43.2 mg dimethoate /kg BW; and 43.2 mg dimethoate plus 100 mg ginger/kg BW. Rabbits were orally managed the particular measurements each other day for 12 weeks. Results indicated that treatment with ginger alone caused significant (P<0.05) increase in body weight (BW) and relative weight of testes compared to control animals. Whereas the rabbits treated with dimethoate showed significant (P<0.05) decrease in BW and relative weight of testes compared with control. Results showed that treatment with DM caused significant (P<0.05) decrease activity of testosterone, T3 and T4. While, increase the levels of FSH and LH in plasma. Ginger caused significant (P<0.05) increase in the activity of testosterone, T3 and T4 in plasma compared to control. While, decrease the levels of FSH and LH in plasma. The presence of ginger with DM caused significant (P<0.05) decrease in the reduction of T3 and T4, while caused an improvement in the levels of testosterone as compared to control and the presence of ginger with DM caused increase in the levels of FSH and LH as compared to control, and this means that ginger counteracted the toxic effects of DM.