A neoplasm, also referred to as a tumor, is an abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of normal tissue and remains in the same excessive manner even after removal of the stimuli which evoked the changes. Tumors may be either benign or malignant. Benign tumors remain localized and are amenable to surgical removal, whereas malignant tumors, i.e. cancerous ones, adhere to any part in an obstinate manner, often invade surrounding tissue, and metastasize to distinct sites. Breast cancer occupies second place as the most occurring cancer in terms of incidence. Breast cancer is a heterogenous cancer, mostly linked with reproductive and hormonal factors in its occurrence. Nulliparous, younger age at menarche, early age pregnancy, older age at first live birth, late menopause, prolonged interval between menarche and first pregnancy, repeated abortions, first pregnancy after 35 years, and no/less breastfeeding are major risk factors for breast malignancies. Recent studies have shown that the implications of reproductive and hormonal factors in patients with breast cancer are associated mostly with BRCA1 (breast cancer gene 1) and BRCA2 (breast cancer gene 2) gene mutations.
<p class="abstract"><strong>Background:</strong> As cases of cancer in women are increasing day to day, it is mandatory to assess risk factors associated with female cancer patients. Our study is designed to elucidate different reproductive factors associated with female cancer patients attending hospital.</p><p class="abstract"><strong>Methods:</strong> 200 female patients who attended the hospital with cancer are studied by asking questions directly to patients following a standard questionnaire regarding reproductive factors like age at menarche, age at first child birth, age at first sexual intercourse, breastfeeding, age at menopause. It was a Retrospective study analyzed via MS Excel calculations. </p><p class="abstract"><strong>Results:</strong> In this study it explains that in female cancer cases, mostly patients were seen having early menarche, also women were in menopause stage mostly, and mostly lactating mothers with breast feeding frequency up to 1-2 years are seen. It also explains that in female cancer cases, women mostly had young maternal age at first child, with carcinoma of cervix and carcinoma of breast reported mostly.</p><p class="abstract"><strong>Conclusions:</strong> In this study we conclude that in females who have early menarche, women with early age at first sexual intercourse, age at first pregnancy, are strongly interrelated and have increased risk of carcinoma. The changes which result in relative risk of cancer associated with menopause are believed to be due to increase in body mass index (BMI), which makes adipose tissue the main site of estrogen production after menopause. Hence, identifying these factors which may be associated with the process of carcinogenesis development in females.</p>
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