Background: Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. It occurs due to blockage of blood vessels supplying the area of the heart. Increased age, diabetes, hypertension, dyslipidemia, and significant alcohol history are some of the major risk factors for acute coronary syndrome (ACS). After coronary angiography, (CAG) angioplasty is the mainstay of treatment. Objectives: The objectives were: (1) To assess the clinical profile of patients with ACS. (2) To study the angiographic profile of patients with ACS. Materials and Methods: A cross-sectional study of 110 patients who underwent CAG at a tertiary care teaching hospital, Amritsar, from April 2021 to July 2022 was studied. Detailed history and echocardiographic findings were obtained. Angiographic findings were studied with management. Data were analyzed using SPSS (version 22) and Chi-square test. Results: Double-vessel disease was the most common angiographic abnormality in unstable angina and ST-elevation myocardial infarction (STEMI); whereas in non-STEMI, triple-vessel disease was the most common. The left anterior descending artery was the most common artery involved. Patients with the age of 51–60 years were the most commonly involved patients, and males had a more severe form of CAD. Smoking did not affect the severity of the disease. Conclusions: Increased age, male sex, and patients with diabetes mellitus, hypertension, and dyslipidemia were predisposed to develop ACS. Smoking did not affect the severity or pattern of artery involvement.

Ankylosing spondylitis (AS) is an inflammatory disorder affecting the axial skeleton and peripheral joints. It is immune-mediated common in the second and third decades having symptoms such as sacroiliitis, synovitis, and difficulty in movement of the spine. It is treated with nonsteroidal anti-inflammatory drugs (NSAIDs), JAK 2 inhibitors, and other biologicals such as infliximab and etanercept. This is the case report of a 24-year-old male student who presented with lower backache, and morning stiffness which improved with activity. On investigation, his HLA B 27 was positive and erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were raised. He was treated with tofacitinib for 1 year, later he developed pott's spine as its side effect. This case report represents the rare side effect of tofacitinib as pott's spine.

Erlotinib is a reversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, competitively inhibiting adenosine triphosphate (ATP) binding at the active site of the kinase. It is approved for treatment of advanced and metastatic cancers. The objective of this report is to find out the cause of the papulopustular lesion while the patient is on tyrosine kinase inhibitor. Our 57-year-old male known case of metastatic pancreatic cancer is on injection gemcitabine 1400 mg (D1 and D8), injection carboplatin 450 mg (D1), and tablet erlotinib 150 mg OD since 1.5 months and after 3 weeks of therapy he developed papulopustular lesions over legs and face which is a side effect of tablet erlotinib and thus it is discontinued and now the patient is being treated for papulopustular lesion by oral and topical antibiotics.

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Hypopituitarism is defined as deficiency of all anterior pituitary hormone1. Panhypopituitarism is defined when there is deficiency of both anterior and posterior pituitary hormone. In this case report our 50 year old male diagnosed with pituitary apoplexy (bleeding in rathke’s pouch) started on intravenous steroids and later on oral steroids and he started improving clinically.