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Background and Aim. Aparallel, randomized, double blinded, placebo-controlled trial study was designed to assess the efficacy of single low dose of intravenous magnesium sulfate on post-total abdominal hysterectomy (TAH) pain relief under balanced general anesthesia. Subject and Methods. Forty women undergoing TAH surgery were assigned to two magnesium sulfate (N = 20) and normal saline (N = 20) groups randomly. The magnesium group received magnesium sulfate 50 mg·kg−1 in 100 mL of normal saline solution i.v as single-dose, just 15 minutes before induction of anesthesia whereas patients in control group received 100 mL of 0.9% sodium chloride solution at the same time. The same balanced general anesthesia was induced for two groups. Pethidine consumption was recorded over 24 hours precisely as postoperative analgesic. Pain score was evaluated with Numeric Rating Scale (NRS) at 0, 6, 12, and 24 hours after the surgeries. Results. Postoperative pain score was lower in magnesium group at 6, 12, and 24 hours after the operations significantly (P < 0.05). Pethidine requirement was significantly lower in magnesium group throughout 24 hours after the surgeries (P = 0.0001). Conclusion. Single dose of magnesium sulfate during balanced general anesthesia could be considered as effective and safe method to reduce postoperative pain and opioid consumption after TAH.

Infections caused by Bordetella pertussis (B. Pertusis), have recently been reported increasingly even in highly immunized populations. This is a population-based, descriptive study. Nasopharyngeal sampling was performed in school children between 6-14 years old with coughing for two weeks or more but without any proved underlying diseases. The specimens were examined for B. Pertusis and Bordetella parapertussis (B. parapertusis) by Polymerase chain reaction and culture. Out of 6601 students, 21 (6.40%) children were found to be positive by polymerase chain reaction assay for B. Pertusis and 6 (2.43%) children had this test positive for B. parapertusis. B. Pertusis was detected in the culture of 4 (1.22%) specimens (all culture positive cases were positive for Polymerase chain reaction too) and B. parapertusis culture was not found positive at all. The estimated incidence of pertussis in this age group was 318/100000 and for B. parapertusis was 2/100000. Pertussis has to be considered as one of the etiologies of prolonged cough in children and adolescents in Iran.

In this multicenter study, we compared the status of antibody production in health care personnel before and after the vaccination using different brands of COVID-19 vaccines between March 2021 and September 2021. Out of a total of 962 HCP enrolled in our study, the antibody against the S1 domain of SARS-CoV-2 was detected in 48.3%, 95.5%, and 96.2% of them before, after the first, and the second doses of the vaccines, respectively. Our results showed post-vaccination infection in 3.7% and 5.9% of the individuals after the first and second doses of vaccines, respectively. The infection was significantly lower in HCP who presented higher antibody titers before the vaccination. Although types of vaccines didn't show a significant difference in the infection rate, a lower infection rate was recorded for AstraZeneca after the second vaccination course. This rate was equal among individuals receiving a second dose of Sinopharm and Sputnik. Vaccine-related side effects were more frequent among AstraZeneca recipients after the first dose and among Sputnik recipients after the second dose. In conclusion, our results showed diversity among different brands of Covid-19 vaccines; however, it seems that two doses of the vaccines could induce an antibody response in most of HCP. The induced immunity could persist for 3-5 months after the second vaccination course.

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