(In suspensions containing secretory vesicles as well as sheets of cell membrane, release of vasopressin parallel to intervesicular fusion and fusion of secretory vesicles with sheets of cell membrane was observed after exposure to Ca 2+ . Mg 2+ and Sr 2+ were ineffective in replacing Ca 2+ as trigger for fusion or vasopressin release.Intervesicular fusion and exocytotic profiles were observed when isolated neurohypophyses or neurosecretosomes were exposed to cold. IntroductionIt is well established that the passage of.Ca 2+ across the cell membrane is a critical step in stimulus-secretion coupling in the neurohypophysis [1,2,3]. Although Ca 2+ influx is apparently too small to be reliably quantitated [4], experiments with Ca 2+ transport inhibitors [2] bear out this contention. Also, treatment of isolated neurohypophyses with ionophores, which increase intracellular, free Ca 2+ concentration by increasing transmembrane transport, can induce secretion [5,6]. Both ultrastructural [7] and biochemical [8,9] studies suggest that secretion in the neurohypophysis as in various other endocrine systems [10], occurs by exocytosis. However, the events that are triggered by
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