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During present assessment 73.9 % donors were hypertensive out of which 30.4% were on single, 34.8% on two and 8.7% on triple antihypertensives.The pre-donation Systolic BP was < 120mmHg in 7.2%, 120-139 mmHg in 88.4%, 140-159 mm Hg in 4.3%. At the time of study, 70.8% donors had SBP ranging from 140 -160mm Hg, 29.2% in the range of 120 -139 mm Hg (pre-hypertensive).Pre-donation, 34.8% donors had DBP < 80 mm Hg , 56.5 % -80-89 mm Hg and 8.7% in range of 90-99 mmHg.At the time of study 63.1% had DBP -90 -99 mm Hg , 30.7 % had DBP -80-99mm Hg , and 6.2% < 80 mm Hg .There was a significant increase of SBP, DBP and mean number of antihypertensives required.There were 42 elderly donors (> 60 years) and 23 younger donors ( < 60 years ). The mean e-GFR decreased significantly in both the groups but the percentage fall was similar in both the groups.22.3% donors developed DM post donation. The BMI of 62.3% donors was between 18.5-25 and in 37.7% it was 25 -30.We excluded donors with BMI >30. At present 81.5% donors have BMI -25 -30 (overweight ) , 6.2% have BMI >30 and 12.3% < 25. There was a significant increase in the mean BMI post donation.7.2 % of donors had a moderate proteinuria (30-300 mg/24 hours ) at the time of donation compared to 49.2% at follow-up. 71.8% donors who developed proteinuria were hypertensives. The degree of proteinuria also increased significantly over the follow up duration. Conclusions: Although the ever increasing demand for kidney donors has led to the procurement of kidneys from medically complex donors, they should be assessed for morbidity / mortality in future as we found a statistically significant deterioration in renal function, Systolic and Diastolic BP and BMI over the follow-up period.

Background: Delayed graft function (DGF) and acute rejection (AR) are common complications in kidney transplant patients. Objectives: The study evaluated DGF and AR in highly sensitized patients and their effects on kidney function for six months post-transplantation. Methods: We enrolled 95 patients with kidney transplants from living donors who were divided into two groups. Group 1 included 47 highly sensitized patients with panel reactive antibody (PRA) < 20.0% and negative donor-specific antigen, and group 2 included 48 patients with negative PRA. All patients were followed for the state of DGF, AR, and kidney function for six months. Results: Group 1 showed a significantly higher proportion of DGF and AR than group 2 (27.7% versus 2.1%, P < 0.001 and 14.9% versus 2.1%, P = 0.031, respectively). The rates of positive PRA in DGF and AR patients were significantly higher than those in non-DGF and non-AR patients (92.9% versus 42.0%, P < 0.001 and 87.5% versus 46.0%, P = 0.031, respectively). Transplanted kidney function was significantly worse in patients with PRA and DGF and/or AR than in patients with negative PRA and non-DGF and non-AR only in the seventh-day post-transplantation. Conclusions: Kidney transplant in highly sensitized patients with positive PRA was related to the increased ratio of DGF and AR.