Artemether is a popular anti-malarial drug; it is an artemisinin derivative in which the lactone has been converted to the corresponding lactol methyl ether (figure 1A). It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria (for treatment of acute uncomplicated malaria) (Kayla et al., 2012). Artemisinin is extracted from which is a Artemisia annua common type of wormwood native to temperate Asia.In traditional Chinese medicine is traditionally Artemisia annua used to treat fever. The proposed mechanism of action of artemisin involves cleavage of endoperoxide bridges by iron, producing free radicals which damage biological macromolecules causing oxidative stress in the cells of the parasite. Anti-malarial drug artemisinin and its derivatives have several other important properties which include anticancerous properties. This class of drug can be a therapeutic alternative in highly aggressive cancer with rapid dissemination, without developing drug resistance. They also exhibit synergism with other anticancer drugs with no increased toxicity towards normal cells. They arrest cell cycle at G /G and regulate several important 0 1 factors that control several pathways that effect drug response, drug interaction etc. Newly developed synthetic artesemenins have been reported to show considerable anti-neoplastic activity, but information is still scarce (Das, 2015a). Considerable anti-tumour activity has been observed in animal models when artemisnin derivative

Physalis minima L. and Physalis peruviana L. are the two important species in India which grow under wild, weedy or cultivated conditions. Fruits of these species are edible with high nutritional values and may be suitable for stuff for the production of new functional foods and drinks. Climate change has been reported to influences almost every aspects of agriculture. Rise in atmospheric CO2 and temperature have been reckoned the two most significant variables involved in climate change. A study was conducted in open top chambers (OTCs) to understand the effect of elevated temperature (ambient + 2±0.5 o C) and elevated CO2 (550±50 ppm) individually and in combination on P. minima and P. peruviana. Study showed that elevated temperature as well as elevated CO2 individually and in combination had positive effect on growth and development, rate of photosynthesis, and water use efficiency of both the Physalis species. Rate of transpiration and stomatal conductance increased marginally in plants grown at elevated temperature, but a marked decrease was evident at elevated CO2 individually and in combination with elevated temperature as compared that in plants grown in ambient conditions in both the species. No significant changes were observed in relative water content and relative stress injury under any of the treatments in two species. Treatmentsand species-specific changes were evident with respect to the activity of antioxidant enzymes and nitrate reductase, and peptide banding pattern using SDS-PAGE.

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A study was conducted in open top chambers (OTCs) to understand the effect of elevated temperature (ambient+2±0.5oC) and elevated CO2 (550±50 ppm) individually and in combination on Chenopodium album. Impact of the climate variables was studied in terms of selected plant attributes, viz., leaf area, RGR etc. Study showed that elevated temperature as well as elevated CO2 individually and in combination had significant positive effect on growth and development, rate of photosynthesis, and water use efficiency of the Chenopodium album. Rate of transpiration and stomatal conductance increased marginally in plants grown at elevated temperature, but a marked decrease was evident at elevated CO2 individually and in combination with elevated temperature as compared that in plants grown in ambient conditions in the Chenopodium album. No significant changes were observed in relative water content and relative stress injury under any of the Chenopodium album. Treatments changes were evident with respect to the activity of antioxidant enzymes and nitrate reductase and peptide banding pattern using SDS-PAGE. This research was conducted to examine the joint effects of increased temperature and elevated CO2 level onChenopodium album (C3 weed). Results from this experiment suggested that rising (CO2) could alter physiochemical response for growth and development of Chenopodium album and it is well defined competitors with different crops in current changing climate conditions.