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In entity-relation (ER) graphs (V, E), nodes V represent typed entities and edges E represent typed relations. For dynamic personalized PageRank queries, nodes are ranked by their steady-state probabilities obtained using the standard random surfer model. In this work, we propose a framework to answer top-k graph conductance queries. Our top-k ranking technique leads to a 4× speedup, and overall, our system executes queries 200-1600× faster than whole-graph PageRank. Some queries might contain hard predicates i.e. predicates that must be satisfied by the answer nodes. E.g., we may seek authoritative papers on public key cryptography, but only those written during 1997. We extend our system to handle hard predicates. Our system achieves these substantial query speedups while consuming only 10-20% of the space taken by a regular text index.

A combination of solid dispersion and surface adsorption techniques was used to enhance the dissolution of a poorly water-soluble drug, BAY 12-9566. In addition to dissolution enhancement, this method allows compression of the granulated dispersion into tablets. Gelucire 50/13 (polyglycolized glycerides) was used as the solid dispersion carrier. Hot-melt granulation was performed to adsorb the melt of the drug and Gelucire 50/13 onto the surface of Neusilin US2 (magnesium alumino silicate), the surface adsorbent. Dispersion granules using various ratios of drug-Gelucire 50/13-Neusilin US2 were thus prepared. The dissolution profiles of BAY 12-9566 from the dispersion granules and corresponding physical mixtures were evaluated using USP Type II apparatus at 75 rpm. The dissolution medium consisted of 0.1 N hydrochloric acid (HCl) with 1% w/v sodium lauryl sulfate (SLS). Dissolution of BAY 12-9566 from the dispersion granules was enhanced compared to the physical mixture. The dissolution of BAY 12-9566 increased as a function of increased Gelucire 50/13 and Neusilin US2 loading and decreased with increased drug loading. In contrast to the usually observed decrease in dissolution on storage, an enhancement in dissolution was observed for the dispersion granules stored at 40 degrees C/75% relative humidity (RH) for 2 and 4 weeks. Additionally, the flow and compressibility properties of dispersion granules were improved significantly when compared to the drug alone or the corresponding physical mixture. The ternary dispersion granules were compressed easily into tablets with up to 30% w/w drug loading. The extent of dissolution of drug from these tablets was greater than that from the uncompressed dispersion granules.

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