The aim of present investigation is to study the efficacy and safety of tranexamic acid in reducing blood loss during and after cesarean section. Tranexamic acid is a competitive inhibitor of plasminogen activation, and at much higher concentrations, a noncompetitive inhibitor of Plasmin. Plasmin may be formed by conformational changes in plasminogen, it's binding to and dissolution of the fibrin matrix is inhibited. Tranexamic acid significantly reduces the amount of blood loss during and after the lower segment cesarean section. The use of tranexamic acid was not associated with any side effects or complication like thrombosis, nausea, vomiting and diarrhea.

Migration of Ascaris lumbricoides into the gallbladder is rare, unlike ascariasis of the bile duct and when it does occur, treatment is generally by endoscopic or surgical extraction. We describe a case of the successful treatment of gallbladder ascariasis with conservative therapy.

Introduction: Adiponectin is the most abundant adipocytokines secreted from adipose tissues and circulates in considerably high concentration in human plasma. Circulating adiponectin levels are decreased in obese subjects and this decrease has been thought to play a crucial role in the early development of atherosclerosis and cardiovascular diseases. Changes in adiponectin concentration has been reported in dyslipidemic subjects, but the evidence is controversial and no study conducted in north Indian population. Moreover, low molecular adiponectin seems to be linked with a worse lipid profile leading to dyslipidaemic through an association with triglyceride but the exact role of adiponectin in modulating lipid fraction is not well established. Aim: To correlate the level of serum adiponectin with lipid fractions in dyslipidemic male subjects and also to compare them with apparently healthy individuals. Materials and Methods: This case control study was conducted from April 2015 to November 2016 in the Biochemistry department of Rajshree Medical Research institute, Bareilly, Uttar Pradesh, India. A total of 70 non diabetic dyslipidemic male subjects between the age group 35 years to 55 years were selected and all the biochemical parameters (adiponectin, fasting plasma glucose, lipid profile) were evaluated and compared with 70 apparently healthy controls. Statistical analysis was performed by licensed version of Statistical Package for Social Sciences (SPSS) 16.0 software. All the data were expressed in “mean±SD”. Student ‘t’ test was also applied to see statistical significance in adiponectin levels between dyslipidemic subjects and healthy controls. Results: The study shows mean±SD of age in dyslipidemic group was 43.61±4.85 years and for control group was 43.53±5.53 years. The mean±SD of BMI in dyslipidemic group 25.72±2.43 was significantly higher than control group 23.42±1.56 with p-value <0.0001. The serum adiponectin concentration was significantly reduced in dyslipidemic subjects 5.11±2.04 μg/mL as compared to healthy control 6.79±1.37 μg/mL with p-value <0.0001. Serum total cholesterol, triglyceride and Low Density Lipoprotein (LDL)- cholesterol were found to be negatively correlated with serum adiponectin (r= -0.89, -0.76 and -0.74) and positively correlated with High Density Lipoprotein (HDL)-cholesterol (r= 0.70). Conclusion: The present study revealed that hypoadiponectinemia is associated with dyslipidaemic in men. The main observation of our present study, however, is that in dyslipidemic subjects, lower levels of adiponectin were associated with high total cholesterol, triglyceride, LDL-cholesterol and reduced HDL cholesterol, though more extensive, multicentric, prospective research with increase sample size could obtain wider insights.

Introduction: The present study was designed to evaluate the association of dyslipidemia (abnormal lipid metabolism) in pre-eclampsia in comparison with non pregnant women, normotensive pregnant women and post partum subjects. Material ad Methods: This study was conducted on 200 subjects who were further divided in four groups (50 subjects in each group). The four groups were non pregnant subjects, normotensive pregnant subjects, pre-eclamptic patients and post partum subjects. Each serum sample from different groups was evaluated for total cholesterol (mg/dl), HDLcholesterol (mg/dl), LDL-cholesterol (mg/dl), VLDL-cholesterol (mg/dl) and triglyceride (mg/dl). Result: On comparison of non pregnant subjects, normotensive pregnant subjects and post partum subjects with pre-eclamptic patients, the levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides were found to be significantly increased (p values ≤ 0.001) and that of HDL cholesterol levels were found to be statistically significantly (p values ≤ 0.001) in pre-eclamptic patients. Conclusion: Deranged lipid metabolism in pre-eclampsia is associated with development of atherosclerotic diseases which increases the morbidity and mortality in mother as well as foetus. The various factors responsible for development of dyslipidemia and its prevention need to be studied and evaluated.