No abstract

Background: Incidence of postoperative liver dysfunction continues to be high (ranging from 10 to 35%) in those who underwent cardiac surgeries using cardiopulmonary bypass (CPB) and is associated with considerable morbidity and mortality. Prolonged cardiopulmonary bypass time (CPBT) was found to be an independent predictor of postoperative liver dysfunction. So, the aim of this study was to evaluate the effect of prophylactic use of N -acetylcysteine (NAC) in patients undergoing on-pump cardiac surgery with expected prolonged CPBT in the prevention of liver dysfunction. Methods: Sixty consenting adult patients undergoing cardiac surgeries using CPB with CPBT more than 120 minutes were included in this single-centre, randomised, parallel-group, double-blinded interventional study. Study group patients received NAC as per the protocol. Liver transferases, alkaline phosphatase, serum bilirubin, kidney function tests, and coagulation parameters were measured preoperatively, on the day of surgery and for 3 days postoperatively. Results: Values for serum aminotransferase, alanine aminotransferase, and alkaline phosphatase were significantly raised in the control group compared to the study group, starting from the day of surgery till third postoperative day. Serum bilirubin levels (total and direct) were comparable till first postoperative day and were significantly raised on second and third postoperative days in the control group. Duration of mechanical ventilation, total chest tube drainage, the duration of ICU and hospital stay were significantly shorter in study group compared to control group. Conclusion: Prophylactic intravenous NAC has a protective role in preventing postoperative hepatic dysfunction in patients undergoing cardiac surgery with CPB.

Background: Idiopathic trigeminal neuralgia (TGN) is a chronic pain disorder causing unilateral, severe brief stabbing recurrent pain in the distribution of one or more branches of the trigeminal nerve. Conventional radiofrequency (CRF) and pulsed radiofrequency (PRF) are two types of minimally invasive treatment. CRF selectively ablates the part of ganglion to provide the relief, but it has been found to be associated with some side effects such as dysesthesia or sensory loss in 6%–28% and loss of corneal reflex in 3%–8% of patients. PRF is a comparatively newer modality which is a nondestructive and neuromodulatory method of delivering radiofrequency energy to the gasserian ganglion to produce a therapeutic effect. Aims: We aimed to compare the efficacy of CRF with long-duration, fixed voltage PRF in the treatment of idiopathic TGN. Setting: This study was conducted in a tertiary care center research institute. Study Design: This was a prospective randomized trial. Materials and Methods: Twenty-seven adult patients of TGN were included in the study and randomly allocated into two groups (CRF and PRF). All procedures were performed operation suite with C-arm fluoroscopic guidance. Both, pre- and postprocedure, the patients were assessed for pain on the Visual Analog Scale (VAS) and Barrow Neurological Institute (BNI) Pain Intensity Scale at 1 week and thereafter at 1, 2, 3, and 6 months. Patients with a BNI score ≥4 after 1 month were considered a failure and offered other modes of treatment. A reduction in VAS score ≥50% and a BNI score <4 were considered as effective. Statistical Analysis: Discreet variables were recorded as proportions, ordinal variables and continuous variables with non-Gaussian distribution as medians with interquartile range, and continuous variables with Gaussian distribution as mean ± standard deviation. Association between ordinal variables was tested by Fisher's exact test/Chi-square test whenever appropriate. Equality of means/median was tested by using paired/unpaired t -test or nonparametric tests depending upon the distribution of data. P ≤ 0.5 was considered statistically significant. Data analysis was performed using STATA version 13.04 windows. Results: Efficacy in terms of decrease in VAS ≥50% at 1 month was 33.33% and 83.33% in the PRF and CRF groups, respectively, which was statistically significant( P = 0.036). Effective reduction in BNI scores at the 7 th day, 1 month, and 2 months postprocedure was evaluated and found in 41.67% and 83.33% of patients in the PRF and CRF groups, respectively, which was statistically insignificant ( P = 0.089). There was a statistically significant reduction in BNI scores in PRF and CRF group patients at 3 and 6 months (at 3...