The present review aims at summarizing the major therapeutic roles of resveratrol and omega-3 fatty acids (O3FAs) along with their related pathways. This article reviews some of the key studies involving the health benefits of resveratrol and O3FAs. Oxidative stress has been considered as one of the most important pathophysiological factors associated with various cardiovascular disease conditions. Resveratrol, with the potent antioxidant and free radical scavenging properties, has been proven to be a significantly protective compound in restoring the normal cardiac health. A plethora of research also demonstrated the reduction of the risk of coronary heart disease, hypertension, and stroke, and their complications by O3FAs derived from fish and fish oils. This review describes the potential cardioprotective role of resveratrol and O3FAs in ameliorating the endoplasmic reticulum stress.

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Abstract; The antioxidant, hepatoprotective, and anthelmintic activities of methanol extract of leaves of Urtica dioica L. (MEUD) were investigated in the present study. Hepatoprotective potential of the extract was evaluated against CCl 4 -induced hepatic injury in Wister rats. In addition, reducing power assay, determination of total antioxidant activity, DPPH radical scavenging activity and nitric oxide scavenging activity were investigated to evaluate the in vitro antioxidant activity of the extract. The results indicated significant antioxidant activity of the extract comparable to standard antioxidant compounds like -tocopherol, ascorbic acid and BHA (Butylated hydroxyanisole). Significant hepatoprotective profile was also observed with maximum hepatoprotection at the dose of 400 mg/kg as suggested by decreased level of serum ALT, AST, ALP and total bilirubin levels towards normalization. Pretreatment of animals with the extract at all the dose level (100, 200, and 400 mg/kg) resulted a significant decrease in malonyldehyde (MDA) level as well as a significant increase in superoxide dismutase (SOD) level clearly indicating inhibition of lipid peroxidation and improvement of antioxidant defense enzyme system. Anthelmintic activity of the methanol extract was also investigated using adult Indian earth worms (Pheretima posthuma) and the results revealed a dose dependent increase in anthelmintic activity of the extract at 25, 50, and 100 mg/mL concentrations.

Drug delivery to the eye is challenging for formulation scientists due to physiological barriers that separate the eye from the rest of the body. A variety of ocular disorders demand the development of optimal drug delivery systems for the administration of drugs and therapeutic agents that can overcome barriers that restrict drug bioavailability. SiRNA inhibits the expression of target genes and has immense potential as a biological tool for the therapeutic inhibition of disease causing genes; however, delivery of siRNA to ocular tissue is a challenge. Recent literature suggests that nanoplatforms show great promise in enhancing ophthalmic drug delivery. A drug delivery system involving nanoparticles and siRNA could surpass problems faced in ocular delivery with improved biodistribution and lower toxicity. This review covers recent research in the area of nanocarrier siRNA drug delivery for various ocular disorders.