Background: Congenital infections are transmissible in utero and it can lead to serious foetal outcomes. These infections can be early detected in pregnant women with bad obstetric history for better foetal outcomes.
Aim of the Study was to evaluate the association of TORCH infection with bad obstetric history among pregnant women.
Study Design: Observational and comparative study
Place and Duration of Study: Central laboratory, Department of Microbiology, SMS Medical College, Jaipur between April 2020 and September 2021.
Methodology: 260 blood samples of pregnant women (130 with bad obstetric history and 130 pregnant women without bad obstetric history) were collected. and tested for the presence of IgM and IgG antibodies against Toxoplasma gondii, Rubella virus, Cytomegalovirus by Chemiluminescence and Herpes simplex virus using ELISA kits.
Results: Overall TORCH IgM seropositivity in high-risk pregnant women was 17.19%. In pregnant women with bad obstetric history, IgM Seropositivity for Toxoplasma gondii was 3.84% (P value .02), rubella 2.34% (P value .30), Cytomegalovirus 5.47% (P value .08), and 6.25% (P value .56) for Herpes-1 and 2 infections and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 16.41% (P value .001), 93.75% (P value .11), 98.44% (P value .55), 48.44% (P value .53) respectively. In pregnant women without bad obstetric history, IgM and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 0/0.77%, 0.76/97.69%, 1.53/99.23% and 4.61/44.62% respectively. The average age of the study population was 27.13 years.
Conclusion: As TORCH infections are transmissible in-utero in all the stages of pregnancy and contributes in neonatal and infant deaths, so early diagnosis and appropriate interventions necessary which help in proper management of the pregnant women.
Background: Organophosphate poisoning is poisoning due to organophosphates (OP’s), used in insecticides, medications and nerve agents. It occurs mostly during suicide attempts in the farming areas, developing world and less by accident. The study is to evaluate the drugs used, respiratory conditions, complications occurred during course of treatment.Methods: This was a prospective observational study conducted for 9 months in a tertiary care hospital. The study was conducted in a 500 bedded tertiary care hospital in an intensive care unit. The study was conducted for nine months (September 2016 - May 2017).Results: A total of 234 patients who had consumed OPP with known and unknown agents were admitted in the emergency department. Out of which 180 males and 54 females.Conclusions: This study concluded that the patients consumed poison is mainly due to mental disturbances and financial problems. The stress and burden on the life will shows the effect after consumption, the maximum people suffer with respiratory problems due to poison consumption. If the government should take the measures to avoid consumption of poison and availability of poison to the public may overcome the complications and reduce the deaths due to poison.
Introduction: Endoscopic ultrasound guided fine needle aspiration cytology (EUS-FNA) is a preferred minimally invasive modality with low complication rates for cytological diagnosis of various gastrointestinal and mediastinal lesions.The present study was conducted to determine whether rapid on-site evaluation (ROSE) of cytology smears by cytopathologist improves the diagnostic yield of solid mass lesions on EUS-FNA. Material and Methods: Total 112 patients from June 2014 through October 2015 referred for EUS-FNA of solid mass lesions were prospectively enrolled in this single center study out of which 56 were in group-I (without onsite cytopathologist) and 56 in group-II (with onsite cytopathologist). In group-Ι patients cytology slides were prepared by endoscopy nurse. In group-ΙΙ patients cytology slides were prepared, stained and assessed for adequacy of sampling by onsite cytopathologist. The final cytopathological diagnosis (definitely positive, definitely negative or inadequate) was compared between the two groups. Results: A total of 61 EUS-FNA procedures in group I and 59 in group II were performed. Abdominal lymph nodes were the most common target sites in both the groups. A significantly higher number of needle passes were performed without onsite cytopathologist (3.59 vs 2.88; P=0.0001). The final cytopathological diagnosis was definite in 71.4% in group I compared with 87.5% in group II. (P = 0.035) The percentage of inadequate diagnosis was 23.2%, in group I and 8.9% in group II. (P= 0.035) Conclusion: ROSE by cytopathologist and interpretation significantly improves the diagnostic yield of EUS-FNA.
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