<p>ABSTRACT<br />Objective: To study the in vitro anti-inflammatory activity of 4-benzylpiperidine.<br />Methods: This study was conducted to evaluate the in vitro anti-inflammatory activity of 4-benzylpiperidine using in vitro models such as inhibition<br />of albumin denaturation and proteinase inhibitory activity.<br />Results: This study revealed the dose-dependent inhibition of protein denaturation and proteinase inhibitory activity by 4-benzylpiperidine.<br />Conclusion: In the present study, results indicate that the 4-benzylpiperidine possess anti-inflammatory properties. The drug inhibited the heat<br />induced albumin denaturation and proteinase inhibitory activity. It shows dose-dependent significant activity when compared with a standard drug.<br />Hence, this study gives an idea that the 4-benzylpiperidine can be used as a lead compound for designing a potent anti-inflammatory drug which can<br />be used to cure inflammation.<br />Keywords: Anti-inflammatory activity, 4-Benzylpiperidine, Protein denaturation, Proteinase inhibitory activity.</p>

Background: Dentists are required to maintain a high level of precision during manual scaling, polishing and Flossing. As a result of sustained griping activity finger and wrist pain are more common among Dentists. Therefore the excess pinch force, leads to musculoskeletal disorders which in turn affects the functional ability. Study design: An Experimental study. Materials & Methods: The sum of 30 Dental professionals were selected under inclusion criteria into this study, ages between 20 to 35 years with decrease in pinch strength and functional abilities. Selected subjects were randomly allocated into two groups such as experimental group (Pinch strength training and conventional exercise) and control group (Conventional Exercises - Postural corrective exercises, active range of motion exercises, shoulder bracing and shoulder shrugging exercise, Ergonomics advices) were given. The outcome tools used are Modified Sphygmomanometer test and Disabilities of the Arm, Shoulder and Hand Questionnaires (DASH). The Statistical analysis of pre &post test values were analyzed using paired & unpaired ‘t’ test. Result: The result of this study shows that Group A using Pinch strength along with Postural Education were found to be effective over the control group, where only the postural education were done (p <0.0001). Conclusion: Therefore this study concludes that Pinch strength training along with Postural education were proven to be significant in improving Pinch strength and Functional performance among Dentist. Key words: DASH Questionnaires, Functional disabilities, Modified Sphygmomanometer test and Pinch strength training.