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In this work, we utilized a simple condensation process for the effective synthesis of coumarin hydrazone fluorescent tag (CHFT) and the evidence for the formation of CHFT was given through FT-IR, 1 H-NMR, HRMS, UV-Vis and Photoluminescence (PL) spectroscopy. Quantum chemical parameters and molecular electrostatic potential were assessed using DFT investigations. CHFT was found to be aggregation induced emission (AIE) active and exhibited strong cyan blue emission with large stokes shift. The optical band gap (Eg) value was determined by Kubelka-Munk theory. The latent fingerprints (LFPs) developed by synthesized coumarin, exhibited excellent sensitivity, selectivity and low background hindrance on various material surfaces. Further, the synthesised CHFT was employed in anticounterfeiting applications.

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Coumarin and its heterocyclic derivatives have been receiving tremendous attention from synthetic and medicinal chemists owing to their remarkable application in material science as well as pharmacological applications. In the current study, a series of coumarin-coupled benzothiazole hydrazone compounds were synthesized by a two-step process, post which their structural features were investigated with the aid of various spectroscopic techniques. The novel synthesized chromophores displayed an electronic absorption band in a range of 358-428 nm and exhibited a positive solvatochromism character as well as a high molar absorption coefficient in the studied solvents. HOMO-LUMO gap, quantum parameters, and various other pharmacokinetics and ADME-T properties of these compounds were investigated through the computational approach. Biological activity assays revealed that all compounds displayed excellent antibacterial activity compared to the Amoxicillin and have also been studied for their antimycobacterial efficacy against Mycobacterium tuberculosis. Furthermore, molecular docking studies was performed with enoyl-acyl carrier protein reductase (InhA).

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