We study the non-perturbative superpotential generated by D(-1)-branes in type IIB compactifications on orientifolds of Calabi-Yau threefold hypersurfaces. To compute the D-instanton superpotential, we study F-theory compactification on toric complete intersection elliptic Calabi-Yau fourfolds. We take the Sen-limit, but with finite gs, in F-theory compactifications with the restriction that all D7-branes are carrying SO(8) gauge groups, which we call the global Sen-limit. In the global Sen-limit, the axio-dilaton is not varying in the compactification manifold. We compute the Picard-Fuchs equations of elliptic Calabi-Yau fourfolds in the global Sen-limit, and show that the Picard-Fuchs equations of the elliptic fourfolds split into that of the underlying Calabi-Yau threefolds and of the elliptic fiber. We then demonstrate that this splitting property of the Picard-Fuchs equation implies that the fourform period of the elliptic Calabi-Yau fourfolds in the global Sen-limit does not contain exponentially suppressed terms $$ \mathcal{O}\left({e}^{-\pi /{g}_s}\right) $$ O e − π / g s . With this result, we finally show that in the global Sen-limit, the superpotential of the underlying type IIB compactification does not receive D(-1)-instanton contributions.

We use string field theory to fix the normalization of the D-instanton corrections to the superpotential involving the moduli fields of type II string theory compactified on an orientifold of a Calabi-Yau threefold in the absence of fluxes. We focus on O(1) instantons whose only zero modes are the four bosonic modes associated with translation of the instanton in non-compact directions and a pair of fermionic zero modes associated with the two supercharges broken by the instanton. We work with a generic superconformal field theory and express our answer in terms of the spectrum of open strings on the instanton. We analyse the contribution of multi-instantons of this kind to the superpotential and argue that it vanishes when background fluxes are absent.