The acetone (AEAC) and aqueous extracts (AQEAC) of Adina cordifolia, belonging to the family Rubiaceae, were studied for hepatoprotective activity against Wister rats with liver damage induced by ethanol. It was found that AEAC and AQEAC, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent and also significantly increased the levels of total protein. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical studies of blood samples of ethanol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by ethanol and blood samples from the animals treated with AEAC and AQEAC showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells against ethanol induced hepatocellular injury. The effects of AEAC and AQEAC were comparable with standard drug silymarin.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11619 International Current Pharmaceutical Journal 2012, 1(9): 279-284

Herbal drugs aimed to determine the hepatoprotective activity of aqueous extract of Nyctanthes arbortristis bark (AQENA) against paracetamol-induced liver damage (PILD) in rat models. Four groups of rats (n=6) were givens one daily administration of 1gm/kg (negative control), 25mg/kg silymarin (positive control) and AQENA (500mg/kg) for 7 days fallowed by induction of hepatotoxicity using of paracetamol. Various parameters, such as physical parameters, biochemical parameters and microscopic analysis ware used to evaluate the hepatoprotective activity. Results indicate that bark extract would a significant (p<0.05) hepatoprotective activity against inducers. These observations were supported by the histological finding. Conclusions: Findings indicate that AQENA possesses a potent hepatoprotective activity against paracetamol.

Introduction: Praziquantel is used to treat diseases caused by infection with numerous types of internal/gastrointestinal and external parasites. Aim: The aim of this study was to design, formulate and evaluation of Praziquantel loaded nanosponges (PZQ-NSGs) by using factorial design. Methodology: The Determination of Calibration curve by UV visible spectrophotometer and Analytical method validation by UV visible spectrophotometer. The Analytical Techniques Used to Detect Drug-Excipient Compatibility of drug. Results and Discussion: The developed nanosponge drug delivery system were subjected to stability testing at higher temperature and humidity condition i.e. at 40⁰C ± 2⁰C and RH 75% ± 5 % after 6 months as per ICH guidelines. Solid state characterization of freeze dried PZQ-NSGs have been done with FTIR, PXRD, particle size analysis. From above characterization it was observed that, the sample was remained stable at 40⁰C ± 2⁰C and RH 75% ± 5 % even after 6 months. Conclusion: Formulated nanosponges formulation was found to be stable at accelerated stability conditions as per ICH guidelines up to 6 months. Nanosized distribution, amorphous nature, better encapsulation and inclusion complexation with EC were found to be the major drivers for significant improvement in solubility, nanosized particles, dissolution efficiency and stability.

In the current research, rats will be given RIF+INH (hepatotoxic), and the hydoethanol (HEESV) extract of the leaves of Sida veronicaefolia will be tested to see how well it protects the rats' livers from damage caused by the RIF+INH. Liver function tests and serum profiles were used to provide an estimate of the hepatoprotective effects of HEESV at a dose of 500 mg/kg. According to the findings, the extracts of Sida veronicaefolia not only provide a strong hepatoprotective impact by lowering blood levels of serum transaminases (SGPT and SGOT), alkaline phosphate, and total bilirubin, but they also considerably enhance the levels of total protein. The effects of HEESV were quite similar to those of the standard medication silymarin.

In the current research, rats will be given paracetamol (hepatotoxic), and the hydoethanol (HEESV) extract of the leaves of Sida veronicaefolia will be tested to see how well it protects the rats' livers from damage caused by the paracetamol. Liver function tests and serum profiles were used to provide an estimate of the hepatoprotective effects of HEESV at a dose of 500 mg/kg. According to the findings, the extracts of the chosen plant not only provide a strong hepatoprotective impact by lowering blood levels of serum transaminases (SGPT and SGOT), alkaline phosphate, and total bilirubin, but they also considerably enhance the levels of total protein. The effects of HEESV were quite similar to those of the standard medication silymarin.