Pyrazole moiety is considered as the most important therapeutic agent for the treatment of inflammation and inflammation associated cancers. Celecoxib, Ramifenazone, Rimonabant and Lonazolac are some of the commercially available pyrazole moieties which are potent COX‐2 inhibitors and also acts in inhibiting various cancers. Recently there are numerous reviews on the biological significance of pyrazole derivatives. However, this review discusses pyrazole derivatives possessing anti‐inflammatory and anticancer activity (COX inhibition) and also illustrates the recent updates on pyrazole research emphasizing on the medicinal chemistry aspects such as the key structural fragments required for the biological activity. There are series of pyrazoles like di‐substituted, tri‐substituted, tetra‐substituted pyrazoles, pyrazole hydrazones, pyrazoles bearing various other heterocycles, bicyclic fused pyrazoles, tricyclic fused pyrazoles, and miscellaneous class of pyrazoles. All these pyrazoles are being researched as COX inhibitors, anti‐inflammatory and against related disorders like cancer.

Triphala Churna consisting Triphala and its constituents have been revealed to have antibacterial properties against human pathogens. The phenolic ring of phytochemicals has been confirmed to be toxic against microorganisms and hence responsible for antibacterial effect. It has also been found to possess antimicrobial, anti-inflammatory, anti-oxidant, and other properties. The objective of this project is to investigate which bioactive compounds of Triphala churna have antibacterial action and can protect humans from infection. The majority of the molecules in phytochemical examination were positive for ethanolic and acetone extracts and the physicochemical characteristics were within the acceptable limits. <em>In silico</em> data clearly explains that the compounds of Triphala churna follows <em>Lipinski’s rule of five.</em> The toxicity profile and ADME parameters of the compounds revealed that most of the compounds were nontoxic towards carcinogenicity, mutagenicity, and reproductive effect. Based on the energy type of interaction between these molecules and the study protein, molecular docking revealed that the three compounds from Triphala churna own the highest docking score against InhA protein: Terflavin B (-9.67 Kcal/mol), Ellagic acid (-9.37 Kcal/mol), and Corilagin (-8.57 Kcal/mol).