Duchenne Muscular Dystrophy (DMD) is the most common X-linked muscular dystrophy in children, presenting in early child-hood and characterized by proximal muscle weakness and calf hypertrophy in affected boys. There is usually delay in motor development and eventually wheelchair confinement followed by premature death from cardiac or respiratory complications. Treatment modalities such as corticosteroid therapy and use of intermittent positive pressure ventilation have provided improve-ments in function, ambulation, quality of life and life expectancy, although novel therapies still aim to provide a cure for this devastating disorder. Here, we present a case of DMD in a 8 year-old male with remarkable clinical manifestations of Duchenne muscular dystrophy

The lymph nodes, particularly cervical nodes are affected in many infectious, autoimmune, metabolic and malignant diseases because they are the first drainage stations especially among children and can represent an early and subtle clinical sign. A careful choice of diagnostic procedures must be made to permit appropriate treatment. The spectrum of differential diagnoses vary from simple upper respiratory infections to malignant diseases. One such rare condi-tion is Sinus Histiocytosis which is associated with fever, massive bilateral lymphadenopathy. It is known to be associated with SLE or can mimic SLE. The condition commonly present in the first two decades of life. In our case of fever of unknown origin, diagnosis of Sinus Histiocytosis was made by lymph node biopsy but immunological profile was suggestive of mixed connective disorder. The case left a grey area unexplored whether MCTD can mimic or be associated with sinus histiocytosis.