Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide. Any abnormality or dysfunction of the liver leads major impairment of the organ function, which in turn, influences the health of the individual. Alcoholic liver disease (ALD) includes fatty liver, hepatic inflammation, liver cirrhosis, fibrosis, alcoholic hepatitis and finally hepatocellular carcinoma. The metabolism of ethanol generates reactive oxygen species, which play a significant role in the deterioration of alcoholic liver disease. Oxidative stress has been considered as a conjoint pathological mechanism, and it contributes to initiation and progression of liver injury.Antioxidants, phytochemicals, such as polyphenols, regulate the expression of ALDassociated proteins and peptides, namely, catalase, superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase. Application of antioxidants signifies a rational curative strategy to prevent and cure liver diseases involving oxidative stress. Although conclusions drawn from clinical studies remain uncertain, animal studies have revealed the promising in-vivo therapeutic effect of antioxidants on liver diseases. Natural antioxidants contained in edible or medicinal plants often possess strong antioxidant and free radical scavenging abilities as well as antiinflammatory action, which are also supposed to be the basis of other bioactivities and health benefits.

Tea is one of the most widely consumed beverages in the world today, second only to water, and its medicinal properties have been widely explored. The tea plant, Camellia sinensis, is a member of the Theaceae family, and black, oolong, and green tea are produced from its leaves. Since ancient times, green tea has been considered by the traditional Chinese medicine as a healthful beverage. Recent human studies suggest that green tea may contribute to a reduction in the risk of cardiovascular disease and some forms of cancer, as well as to the promotion of oral health and other physiological functions such as anti-hypertensive effect, body weight control, antibacterial, solar ultraviolet protection, bone mineral density increase, anti-fibrotic properties, and neuroprotective power. Increasing interest in its health benefits has led to the inclusion of green tea in the group of beverages with beneficial effects on cancer prevention.

Introduction: Clinically useful non-steroidal antihyperlipidemic drugs are now in the market for the treatment of patients suffering from hypercholesterolemia. Indan acids, which belong to non-steroidal aryl alkanoic acids class acids have been reported to possess varying degrees of cholesterol lowering activity. Keeping the above points in view exploration for better anti-hypercholesterolemic activity of indanyl tetrazole derivatives was undertaken. Methods: Five-week-old male albino Charles Foster rats (120± 10 g) for normocholesterolemic and seven-week-old rats (130±10g) for hypercholesterolemic studies were used. On the 0-day and 14th day, tail vein blood was drawn from the overnight fasted animals respectively. Biochemical measurements were carried out using biochemical kits (Span, India) and an automated biochemical analyzer (Vitros-250, Johnson and Johnson Co. USA). Results: The compound - V and VI exhibited almost same significant level of cholesterol lowering (p<0.01) activity. On closer look its reveal that the compound-VI exhibit triglyceride lowering (p<0.01) activity among the groups around 14 days of treatment on normocholesterolemic rats. Test compound- V (p<0.05) and compound-VI (p<0.001) have significant anti-hyper-cholesterolemic activity while clofibrate has no such activity on hypercholesterolemic rats. Conclusions: Indanyl tetrazole derivatives, 5-(62 -methoxyindan-12 -yl) methyltetrazole (V) and 5- (52 , 62 -dimethoxyindan-12 -yl) methyltetrazole (VI) were more promising than their analogs in respect to their anti-hypercholesterolemic activity. DOI: http://dx.doi.org/10.3126/joim.v32i3.4956 Journal of Institute of Medicine, December, 2010; 32:3 24-29

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