Background: Diabetes Mellitus is the most common endocrine disorder involving almost all systems of body. Untreated or poorly treated Diabetics are susceptible to develop a series of complications responsible for raised morbidity and mortality. Diabetes Mellitus has a number of long term effects on the Genitourinary system. Urinary tract infections have long been recognised as a significant problem in patients with Diabetes Mellitus.Methods: Prospective observational study. Diabetic patients with culture positive UTI were included. Gestational diabetes, Immunocompromised patients and patients with congenital renal anatomical abnormalities were excluded.Results: Authors included 211 numbers of culture positive UTI among diabetic patients. Out of which, 65 were male and 146 were female. Maximum number of patients belong to 56-65 years age group. Escherichia coli was the predominant organism isolated. Gram positive organisms showed 100% sensitivity to Vancomycin and Linezolid. Gram negative organisms showed 100% sensitivity to Polymyxin B.Conclusions: Genitourinary tract infection is not an infrequent complication seen in diabetes patients. Most common causative organism and their antibiotic sensitivity pattern should be done in tertiary care hospital for a better antibiotic policy.

Background: Several types of neurological manifestations are associated with falciparum malaria. Cerebral malaria is one of the most dreaded complications. A significant number of survivors are left with disabling neurological sequelae, most of which are self-limiting. Neurological involvement is more frequent with falciparum malaria because of its unique characteristics leading to micro-vascular involvement.Methods: Present study was conducted at department of General Medicine, VIMSAR, Burla (Odisha). This observational study included in total 110 patients, who were confirmed cases of falciparum malaria. Clinical profile including detailed neurological examination with relevant investigations was done. Spectrum of neuropsychiatric manifestations were observed.Results: Out of 110 patients male and female ratio was 1:1 (M 55 and F 55). The mean age of presentation in male was 36.09 + 14.85 yrs. and in female was 31.85 + 14.00 yrs. The major presenting symptoms were fever, headache, vomiting, altered sensorium, altered behaviour and convulsions in their decreasing order of frequency. On neurological evaluation, diminished level of consciousness was found in 56.4% cases. 14% cases had GCS score ≤ 7 and 63% had GCS score ≥ 11. Convulsion was found in 31% cases, cranial neuropathy in 10.9%, cerebellar dysfunction in 12.7%, neck rigidity in 22.7%, speech abnormality in 3.6%, peripheral neuropathy in 8.2%, fundoscopic changes suggestive of retinal involvement in 44.5% cases. Atypical manifestation like; Intracerebral haemorrhage, subarachnoid haemorrhage, cortical venous sinus thrombosis were also found in few cases. 32.72% patients had Neuropsychiatric manifestations at discharge in the form of focal neurological deficits, psychosis, depression, speech disorder, memory loss, cerebellar abnormality & peripheral neuropathy.Conclusions: Neurological manifestations in falciparum malaria patients are common and encompass a wide spectrum of clinical presentation. In an endemic area, falciparum malaria should be kept as a differential diagnosis in patients presenting with atypical neurological manifestations.

Background:The clinical study of incidence and role of co-morbid conditions in management and outcome of burns patients. The objective of this study was to determine the role of comorbid conditions in burns patient management and to understand the outcome the morbidity and mortality in burns patients with comorbid conditions.Methods: One hundred patients suffering burn injury with associated comorbid conditions had been selected randomly (every third burns patient with associated comorbidity). Co-morbidities associated were noted from history given by the patients. It is a prospective observational clinical study of 2 years of duration. Patients admitted in the department of burns and reconstructive surgery from the 2104 October up to twenty-four months were included in this prospective study.Results: It is a clinical observational prospective study. Study involve 100 burns patients with comorbidities: alcoholics (53%), smokers (15%), diabetic (12%), obesity (7%), psychiatric illness (6%), epilepsy (5%), bronchial asthma (2%). It was observed that morbidity and mortality were more in alcoholic (49%) and diabetic patients (33%) when compared to other co-morbid conditions. Wound infections and delayed wound healing was found more in diabetic patients. Incidence of higher percentage of burns was found in alcoholic patients.Conclusions: This study concluded that comorbid conditions increased the duration of hospital which also affected mortality, with longest stay of 102 days and average duration of stay of patients with co-morbid conditions was 45-65 days.

Objective: to evaluate the incidence of cardiac arrhythmia in chronic cor pulmonale and to focus on the contributing etiological factors. Material & Methods: 35 cases of chronic cor pulmonale were thoroughly examined for the presence of arrhythmia. After recording history & physical examination blood was collected for various investigations like serum potassium, blood urea, blood volume and ABG study before and after the development of arrhythmia. Along with this X-ray & ECG were done in every case. Results: incidence of cardiac arrhythmia among all cor pulmonale patients was found to be 20% of which supraventricular ectopic beats was the most common. Respiratory infection may be thought to be the major factor in the development of congestive heart failure & different cardiac dysarrhythmia. Besides this, not a single possible factor has been found to be associated with cardiac arrhythmia. Conclusion: cor pulmonale has a low incidence in this part of country. Not a single factor associated with cardiac arrhythmia could be found out except pulmonary infection. Further studies are required in this field on a larger number of patients. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8393   Asian Journal of Medical Science Vol.5(1) 2014 pp.15-19