Portraying a robust working-team model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the connect-approach across involved disciplines in the management of CNS malignancies. With its provincial founding-panels and national steering board; NOSC has been operational in Iran since 2011. This initiative has pursued its mission through interval strategic meetings, tumor-boards, case-discussions as well as publishing neuro-oncology updates, case study periodicals and newsletters. A provincial meeting of NOSC in Shiraz, put together insights from international practice guidelines, emerging evidence and expert opinions to draw a position statement on high-grade glioma management in adults. The present report summarizes key highlights from the above clinical forum.

10.30699/jambs.30.141.333 Background & Objective: The lack of breast cancer screening in young women leads to late disease diagnosis and worse outcomes in this age group. This study was designed to evaluate clinicopathological features and long-term outcomes of young breast cancer women in south of Iran. Materials & Methods: This is a retrospective study of breast cancer patients who were pathologically diagnosed during 2005 to 2017. Data from 284 breast cancer patients aged 40 years or younger were included in this study. Demographic, clinicopathological properties as well as treatment modalities including type of surgery, adjuvant radiotherapy, and adjuvant or neoadjuvant chemotherapy were recorded and analyzed.Results: Median age of the patients was 36 (range 23-40) years. After a median follow-up of 68 months, 21 patients had died due to the disease, 59 patients were alive with the disease, and 204 patients were alive without the disease. The univariate COX regression demonstrated that the disease -free survival (DFS) was significantly low in patients who had undergone breast conservation surgery (BCS) and also patients with higher stages, estrogen/progesterone-negative and human epidermal growth factor receptor 2-positive (ER-/PR-/HER2+) status. Low overall survival (OS) was also significantly associated with stage. According to multivariate COX regression, BCS, stages II, III and also young age were independent predictive factors for low DFS. Conclusion:Given the aggressive features and worse outcome of young breast cancer patients, treatment remains tough and screening seems to be required at young age. Further studies are required to find best management and therapeutic protocols for these patients.

Introduction: Salivary gland tumors are rare tumors that account for 3 to 4% of head and neck neoplasms. These tumors may arise from 6 major and numerous minor salivary glands. This study was designed to investigate the factors affecting the prognosis of salivary gland tumors. Methods: This study is a retrospective descriptive study in which the records of patients with salivary gland tumors referred to the Radiotherapy and Oncology Center of Namazi Hospital from 2005 to 2015 were reviewed. Results: 158 patients were included in this study with a mean age of 55.37 years. 49% of the patients were men. Adenoid Cystic Carcinoma was the most common histological type (30.57%) and Adenocarcinoma with a prevalence of 1.91% had the lowest prevalence rate in this study. 65.19% of salivary gland neoplasms in this study had parotid gland involvement and sublingual gland involvement had the lowest prevalence (3.8%). The results of survival analysis clearly illustrated that surgery, pathology type and stage was statistically significant in survival. Discussion: Clinical, pathological and therapeutic factors in people with malignant salivary gland neoplasms have a significant relationship with their survival. controversies on treatment and outcome continues.

Background and Objective: Reduced balance performance is among the most common consequences of chemotherapy-induced peripheral neuropathy in women with breast cancer who receive taxane-based chemotherapy (TBC). We aimed to assess the responsiveness and interrater reliability of the short form of the Fullerton Advanced Balance (SF-FAB) scale in monitoring the balance status of women with breast cancer following a cycle of TBC and the scale's potential to detect balance changes in these people. Methods: In this measurement-focused study, 33 women diagnosed with breast cancer were recruited. After baseline assessments of the SF-FAB and the Revised and Shortened Total Neuropathy Score (TNSr-SF) by 2 raters, participants received 6 to 10 sessions of TBC with a mean interval of 2.61 weeks. After cessation of the chemotherapy cycle, outcomes were reassessed. Twenty-eight participants with a mean age of 46.50 (10.46) years completed the trial. Results: After the interventions, the SF-FAB score decreased significantly (P = .02) and the neuropathy score increased significantly (P < .001), indicating lowered balance and aggravated neuropathy. This study showed excellent interrater reliability for the total score of the SF-FAB, before and after TBC (intraclass correlation coefficient(2,2) ≥ 0.90, 95% confidence interval = 0.96-0.99). The internal consistency of the scale was acceptable (Cronbach's α = 0.97) and a moderate negative correlation was observed between the SF-FAB and neuropathy scores (r = −0.63), which was statistically significant (P ˂ .001). Conclusion: Reliable functional tests that are feasible and easy to apply, such as the SF-FAB scale, contribute to a quick screen of women with cancer who undergo TBC as a preliminary to further comprehensive assessments if necessary.

Portraying a robust working-team model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the connect-approach across involved disciplines in the management of CNS malignancies. With its provincial founding-panels and national steering board; NOSC has been operational in Iran since 2011. This initiative has pursued its mission through interval strategic meetings, tumor-boards, case-discussions as well as publishing neuro-oncology updates, case study periodicals and newsletters. A provincial meeting of NOSC in Shiraz, put together insights from international practice guidelines, emerging evidence and expert opinions to draw a position statement on high-grade glioma management in adults. The present report summarizes key highlights from the above clinical forum.