For many years, clinical and non-clinical investigations have investigated cortical bone structure in an attempt to address questions related to normal bone development, mineralisation, pathologies and even evolutionary trends in our lineage (adaptations). Research in the fields of medicine, materials science, physical anthropology, palaeontology, and even archaeobiology has contributed interesting data. However, many questions remain regarding the histomorphological and histochemical variations in human cortical bone during different stages of life. In the present work, we describe a study of long bone cortex transformations during ontogeny. We analysed cross-sections of 15 human humeri histomorphologically and histochemically from perinatal to adult age, marking and quantifying the spatial distribution of bone tissue types using GIS software and analysing the mineral composition and crystallinity of the mineralised cortex using Raman spectroscopy and X-ray diffraction. Our results allowed us to propose that human cortical bone undergoes three main 'events' through ontogeny that critically change the proportions and structure of the cortex. In early development, bone is not well mineralised and proportionally presents a wide cortex that narrows through the end of childhood. Before reaching complete maturity, the bone mineral area increases, allowing the bone to nearly reach the adult size. The medullary cavity is reduced, and the mineral areas have a highly ordered crystalline structure. The last event occurs in adulthood, when the 'oldest' individuals present a reduced mineralised area, with increasing non-mineralised cavities (including the medullary cavity) and reduced crystalline organisation.

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La imagen de una España interior seca y fría, prácticamente despoblada durante el neolítico y,

Puberty and adolescence represent a significant period of physical growth and maturation and a critical life stage in which children transition into adults within their societies. Numerous studies have observed a secular trend and have determined that puberty is now occurring earlier than in the past. This investigation represents the first application of a methodology for assessing the pubertal status of osteological remains to a prehistoric skeletal sample. Six Bronze Age adolescent skeletons from the Cerro de La Encantada archaeological site (Ciudad Real, Spain) were analyzed. Pre-pubescence was observed at age 9 and the transition phase of the pubertal growth spurt at 15 years of age. These results were similar to those obtained from medieval, Industrial Revolution, and modern populations, both within and outside of the Iberian Peninsula. The similarity in the development of the Bronze Age adolescents to that of other past and contemporary populations suggests that the pubertal process has remained essentially unchanged across millennia until recent times. However, other interpretations, including the influence of a subpar developmental environment and potential methodological artifacts, are possible. Nevertheless, studies of this type provide important information about a crucial transitory period in human development.