A mouse model of cystitis caused by uropathogenic Escherichia coli was used to study the distribution of gallium in bladder tissue following oral administration of gallium maltolate during urinary tract infection. The median concentration of gallium in homogenized bladder tissue from infected mice was 1.93 g/g after daily administration of gallium maltolate for 5 days. Synchrotron X-ray fluorescence imaging and X-ray absorption spectroscopy of bladder sections confirmed that gallium arrived at the transitional epithelium, a potential site of uropathogenic E. coli infection. Gallium and iron were similarly but not identically distributed in the tissues, suggesting that at least some distribution mechanisms are not common between the two elements. The results of this study indicate that gallium maltolate may be a suitable candidate for further development as a novel antimicrobial therapy for urinary tract infections caused by uropathogenic E. coli.

Premature parturition induction may adversely affect postnatal health and performance. The objective of this study was to evaluate the impact of cloprostenol induction 2 d prior to term on piglet maturity (liver glycogen), postnatal productivity (birth weight, growth rate), and health (morbidity, mortality, passive antibody, fecal Clostridium perfringens). Two hundred and sixteen pregnant sows and their progeny (2827 piglets) were assigned to the study. Induction decreased gestation length 2.1 d (P < 0.0001), birth weight 107.2 g pig-1 (P = 0.0004), lactational growth 10.1 g d-1 (P = 0.05), and day 16 weight 0.30 kg pig-1 (P < 0.05). Liver glycogen concentration was 71.2 µg g-1 higher in the stillborns of induced sows (P = 0.03), suggesting the pre-term sows were catabolic. No group differences in post-weaning growth rate, pre-weaning mortality or morbidity, passive antibody transfer or fecal Clostridium perfringens level were found. Reduced lactational growth appeared attributable to the reductions in gestation length and birth weight, rather than in piglet maturity. In spite of reducing lactational growth and body weight at 16 d of age, the administration of cloprostenol 2 d prior to term, under the conditions of this study, resulted in no measureable long-term health or performance consequences. Key words: Porcine, parturition-induction, cloprostenol, prostaglandin F2α, glycogen, Clostridium perfringens