We present a tool for semantic medical image annotation and retrieval. It leverages the MEDICO ontology which covers formal background information from various biomedical ontologies such as the Foundational Model of Anatomy (FMA), terminologies like ICD-10 and RadLex and covers various aspects of clinical procedures. This ontology is used during several steps of annotation and retrieval: (1) We developed an ontology-driven metadata extractor for the medical image format DI-COM. Its output contains, e. g., person name, age, image acquisition parameters, body region, etc. (2) The output from (1) is used to simplify the manual annotation by providing intuitive visualizations and to provide a preselected subset of annotation concepts. Furthermore, the extracted metadata is linked together with anatomical annotations and clinical findings to generate a unified view of a patient's medical history. (3) On the search side we perform query expansion based on the structure of the medical ontologies. (4) Our ontology for clinical data management allows us to link and combine patients, medical images and annotations together in a comprehensive result list. (5) The medical annotations are further extended by links to external sources like Wikipedia to provide additional information. 1 1 This research has been supported in part by the THESEUS Program in the MEDICO Project, which is funded by the German Federal Ministry of Economics and Technology under the grant number 01MQ07016. The responsibility for this publication lies with the authors.

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We created a simple-to-use framework to construct gazeresponsive applications using web technology focussing on text. A plugin enables any compatible browser to interpret a new set of gaze handlers that behave similar to existing HTML and JavaScript mouse and keyboard event facilities. Keywords like onFixation, onGazeOver, and onRead can be attached to parts of the DOM tree and are triggered on the corresponding viewing behavior. The plugin is part of a distributed architecture featuring a remote gaze provider and a number of assisting services and tools. Using this framework we implemented a number of applications providing help on comprehension difficulties.

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