Toxicity has become a ubiquitous, if uneven, condition. Toxicity can allow us to focus on how forms of life and their constituent relations, from the scale of cells to that of ways of life, are enabled, constrained and extinguished within broader power systems. Toxicity both disrupts existing orders and ways of life at some scales, while simultaneously enabling and maintaining ways of life at other scales. The articles in this special issue on toxic politics examine power relations and actions that have the potential for an otherwise. Yet, rather than focus on a politics that depends on the capture of social power via publics, charismatic images, shared epistemologies and controversy, we look to forms of slow, intimate activism based in ethics rather than achievement. One of the goals of this introduction and its special issue is to move concepts of toxicity away from fetishized and evidentiary regimes premised on wayward molecules behaving badly, so that toxicity can be understood in terms of reproductions of power and justice. The second goal is to move politics in a diversity of directions that can texture and expand concepts of agency and action in a permanently polluted world.

Chemical toxicity is part of everyday life in Puchuncaví. The most polluted industrial compound in Chile, Puchuncaví is home of fourteen industrial complexes, including the largest copper smelting plant in the country and four thermoelectric plants. Stories of biological mutation, corrosion and death among plants, humans, fishes and cattle are proliferate in Puchuncaví. Engaging with the growing interest in care and affective modes of attention within STS, this paper examines how ill, intoxicated or otherwise affected people in Puchuncaví act upon and know about their chronic sufferings. Drawing on ethnographic fieldwork, I focus on what I call 'hypo-interventions', or the minimal and unspectacular yet life-enabling practices of caring, cleaning and healing the ailments of their significant others, human and otherwise. By minutely engaging with somatic and affective alterations in the domestic spaces of the body, the home and the garden, Puchuncavinos render industrial harm visible and knowable, and hence a type of political action is invoked. While outside technical validation and alien to conventional politics, these actions have proved crucial for people in Puchuncaví striving to persevere in the face of industrial violence and institutional abandonment. I coin the term 'intimate activism' to describe the ethical and political affordances of the subdued doings and engagements deployed in Puchuncaví. Intimate activism, I claim, draws its political power on its capacity to create minimal conditions for ethical and material endurance.

The article analyzes the effects of the Guggenheim Museum Bilbao (GMB), adopting a new research perspective and trying to pursue the links between the museum and Bilbao's art scene. Until now, the impact of the museum has been analyzed from two different perspectives. The first focused on the urban development and regeneration aspects and the success of the museum as a tourist magnet and an image-making device. The second perspective concentrated on the direct economic benefits of the museum, i.e. direct returns and effects on the economy. The missing lens in previous analyses, however, was the impact of the museum on the city's art landscape, including the art support activities. In this context, the article describes for the first time in a detailed way how the GMB has contributed to the shaping and propulsion of changes on commercial and non-profit art spaces in Bilbao. Although it is clear that other factors may play a role, it can be asserted that the effects of the museum are not only limited to an increase in tourism or fiscal return, but also contribute to the development and spatial articulation of the local art scene and public support of the arts.

How can politics be articulated or at least imagined by ill, impoverished and abandoned communities? This article documents how care is invoked by activist groups and local citizens in their search for ethical recognition and environmental justice in Puchuncaví, Chile. The authors argue that in a context of prolonged and systematic harm, care emerges as a way to render their suffering understandable, knowable and actionable, and thus as a mode of intervention that instantiates politics in different spaces and at several scales. At the interfaces of feminist science studies, environmental sociology and political theory, this article examines how care acts as a grammar to enunciate problems and make connections deemed irrelevant by expert apparatuses. Specifically, the authors ethnographically track the capacity of care practices to create therapeutic spaces of affective endurance and healing, and to produce new forms of sensual and ecological knowledge about beings, things and relations. These different modes of caring and being cared for, it is suggested, underline the capacity of care for the politicization of harm and suffering: to rearrange what is visibilized, valued and problematized in the face of intractable environmental crises-a crucial objective for collectives removed from every form of politics. Care, as it is articulated here, is not a coherent and predefined programme, but a fluid and adaptable ethico-political set of practices and potentialities always concerning specific individuals facing specific problems in specific circumstances. If care is to be mobilized to craft more responseable policy, researchers should think more thoroughly about these multiple configurations of care, and the disparate ways in which they can contribute (or not) to invoke new styles and formats, new sensitivities and possibilities for policy-making.