Objectives Pharmacist-client communication is one of the most significant relationships in the healthcare delivery system. Our study aims to assess the active role of the pharmacist in educating and guiding pharmacy clients who are receiving over-the-counter and/or pharmaceutical preparations properly and safely. Methods This study follows the descriptive and analytical approach by adapting the questionnaire instrument; the questionnaire was distributed through the Internet and the online survey using Google Forms was based on a quantitative measurement to estimate the independent and the dependent variables. Key findings The obtained data confirmed that there are statistically significant effects related to the pharmacist interaction skills (pharmacist’s trust, integrity, responsiveness and empathy) on guiding the consumers in taking medicines and pharmaceutical preparations effectively and safely. Conclusions The pharmacist’s role as a medications expert and member of multidisciplinary healthcare professional team must work in tandem with other healthcare professionals to guard the client’s safety and achieve good therapeutic outcomes.