We present a new code, CASTRO, that solves the multicomponent compressible hydrodynamic equations for astrophysical flows including self-gravity, nuclear reactions and radiation. CASTRO uses an Eulerian grid and incorporates adaptive mesh refinement (AMR). Our approach to AMR uses a nested hierarchy of logically-rectangular grids with simultaneous refinement in both space and time. The radiation component of CASTRO will be described in detail in the next paper, Part II, of this series.

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