The technical complexities and sheer size of international large-scale assessment (LSA) databases often cause hesitation on the part of the applied researcher interested in analyzing them. Further, inappropriate choice or application of statistical methods is a common problem in applied research using these databases. This article serves as a primer for researchers on the issues and methods necessary for obtaining unbiased results from LSA data. The authors outline the issues surrounding the analysis and reporting of LSA data, with a particular focus on three prominent international surveys. In addition, they make recommendations targeted at applied researchers regarding best analysis and reporting practices when using these databases.