We use exceptional field theory to describe locally non-geometric spaces of M-theory of more than three dimensions. For these spaces, we find a new set of locally non-geometric fluxes which lie in the R-R sector in the weak-coupling limit and can typically be characterised by mixed symmetry tensors. These spaces thus provide new examples of non-geometric backgrounds which go beyond the NS-NS sector of string theory. Starting from twisted tori we construct duality chains that lead to these new non-geometric backgrounds and we show that, just as in the four-dimensional case, there are missing momenta associated to the mixed symmetry tensors.

We derive the commutation relations for open-string coordinates on D-branes in non-geometric background spaces. Starting from D0-branes on a three-dimensional torus with H-flux, we show that open strings with end points on D3-branes in a three-dimensional R-flux background exhibit a non-associative phase-space algebra, which is similar to the non-associative R-flux algebra of closed strings. Therefore, the effective open-string gauge theory on the D3-branes is expected to be a non-associative gauge theory. We also point out differences between the non-associative phase space structure of open and closed strings in non-geometric backgrounds, which are related to the different structure of the world-sheet commutators of open and closed strings.