This Working Paper series provides a vehicle for preliminary circulation of research results in the fields of economic development and international trade. The series is intended to stimulate discussion and critical comment. Staff and visitors in any part of the Australian National University are encouraged to contribute. To facilitate prompt distribution, papers are screened, but not formally refereed.

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AIMSleep disturbances induce proinflammatory immune responses, which might increase cardiovascular disease risk. So far the effects of acute sleep deprivation and chronic sleep illnesses on the immune system have been investigated. The particular impact of shift work induced chronic circadian disruption on specific immune responses has not been addressed so far.MethodsPittsburgh-Sleep-Quality-Index (PSQI) questionnaire and blood sampling was performed by 225 shift workers and 137 daytime workers. As possible markers the proinflammatory cytokines IL-6 and TNF-α and lymphocyte cell count were investigated. A medical examination was performed and biometrical data including age, gender, height, weight, waist and hip circumference and smoking habits were collected by a structured interview.ResultsShift workers had a significantly higher mean PSQI score than day workers (6.73 vs. 4.66; p < 0.001). Day workers and shift workers had similar serum levels of IL-6 (2.30 vs. 2.67 resp.; p = 0.276), TNF-α (5.58 vs. 5.68, resp.; p = 0.841) or lymphocytes count (33.68 vs. 32.99, resp.; p = 0.404). Furthermore there were no differences in cytokine levels (IL-6 p = 0.761; TNF-α p = 0.759) or lymphocyte count (p = 0.593) comparing the sleep quality within the cohorts. When this calculation of sleep quality was stratified by shift and day workers irrespective of their sleep quality day workers and shift workers had similar serum levels of IL-6, TNF-α or lymphocytes count. Multiple linear regression analysis showed a significant correlation of lymphocytes count and smoking habits.ConclusionShift work induces chronic sleep debt. Our data reveals that chronic sleep debt might not always lead to an activation of the immune system, as we did not observe differences in lymphocyte count or level of IL-6 or TNF-α serum concentration between shift workers and day workers. Therefore chronic sleep restriction might be eased by a long-term compensating immune regulation which (in healthy) protects against an overstimulation of proinflammatory immune mechanisms and moderates metabolic changes, as they are known from short-term sleep deprivation or sleep related breathing disorders.

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Abstract. The science guiding the EUREC4A campaign and its measurements are presented. EUREC4A comprised roughly five weeks of measurements in the downstream winter trades of the North Atlantic – eastward and south-eastward of Barbados. Through its ability to characterize processes operating across a wide range of scales, EUREC4A marked a turning point in our ability to observationally study factors influencing clouds in the trades, how they will respond to warming, and their link to other components of the earth system, such as upper-ocean processes or, or the life-cycle of particulate matter. This characterization was made possible by thousands (2500) of sondes distributed to measure circulations on meso (200 km) and larger (500 km) scales, roughly four hundred hours of flight time by four heavily instrumented research aircraft, four global-ocean class research vessels, an advanced ground-based cloud observatory, a flotilla of autonomous or tethered measurement devices operating in the upper ocean (nearly 10000 profiles), lower atmosphere (continuous profiling), and along the air-sea interface, a network of water stable isotopologue measurements, complemented by special programmes of satellite remote sensing and modeling with a new generation of weather/climate models. In addition to providing an outline of the novel measurements and their composition into a unified and coordinated campaign, the six distinct scientific facets that EUREC4A explored – from Brazil Ring Current Eddies to turbulence induced clustering of cloud droplets and its influence on warm-rain formation – are presented along with an overview EUREC4A's outreach activities, environmental impact, and guidelines for scientific practice.