Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma, among patients with human immunodeficiency virus infection. Most non-HodgkinNon-Hodgkin's lymphomas (NHL) are the second most frequent malignancies in acquired immunodeficiency syndrome (AIDS) patients. More than 9�% of HIV-associated NHL is derived from B cells and the majority is high-grade and extranodal. The digestive tract is one of the most common extranodal primary sites for NHL in AIDS patients, accounting for ��% of all primary extranodal lymphomas 11 . Burkitt's lymphoma (BL) has frequently been reported as a neoplasm in HIV-infected patients. These lymphomas are now better designated as AIDS-related BL 1 .We report a case of primary BL of the duodenum in an AIDS patient. CASE REPORTA �5-year-old man infected with the human immunodeficiency virus (HIV) and hepatitis C virus (HCV) was admitted to our unit for AIDS-related illness with fever (��°C -��.5°C), anorexia, upper abdominal pain, night sweats and weight loss of three months duration. He had no history of AIDS-defining illness and he had never received highly active antiretroviral therapy (HAART). �hysical examination revealed that he had lost approximately 15kg of weight during the last three months prior to admission. Lung and cardiac auscultation were normal. His abdomen was tender, with spontaneous epigastric and right hypochondrium pain that increased during palpation and hepatomegaly (2cm below the right costal margin). He did not present rebound tenderness.The relevant laboratory findings were: hemoglobin 1�.2g/dl; hematocrit ��%; leukocytes 5,���/mm � ; platelets 15�,���/mm � ; lactate dehydrogenase 1,5�5U/l and alkaline phosphatase 2,��5U/l. Liver function, transaminase level, kidney function and coagulation tests were normal. The CD� T cell count was �7 cell/ul and the plasma viral load was ��,12� copies/ml (log 1� �.�). Multiple blood, urine and sputum cultures were all negative.A chest X-ray was normal. Abdominal ultrasound showed hepatomegaly with increased echogenicity, isoechoic periportal

In 2017, the World Health Organization (WHO) confirmed a new entity, Epstein Barr virus (EBV) + Diffuse large B cell lymphoma (DLBCL), not otherwise specified (NOS). Traces of EBV transcripts were described in lymphomas, including DLBCL, that were diagnosed as EBV negative by conventional methods. The aim of this study was to detect viral genome by qPCR, as well as LMP1 and EBNA2 transcripts, with a more sensitive method in DLBCL cases from Argentina. Fourteen cases originally considered as EBV negative expressed LMP1 and/or EBNA2 transcripts. In addition, LMP1 and/or EBNA2 transcripts were also observed in bystander cells. However, EBERs+ cells cases by conventional ISH showed higher numbers of cells with LMP1 transcripts and LMP1 protein. In the cases that were EBERS− in tumor cells but with expression of LMP1 and/or EBNA2 transcripts, the viral load was below the limit of detection. This study provides further evidence that EBV could be detected in tumor cells by more sensitive methods. However, higher expression of the most important oncogenic protein, LMP1, as well as increased viral load, are only observed in cases with EBERs+ cells by conventional ISH, suggesting that traces of EBV might not display a key role in DLBCL pathogenesis.

Four unreported nonrandom chromosome aberrations in CLL/SLL patients, one of them who might represent a new recurrent abnormality, are described. These uncommon abnormalities, mostly associated with evolving disease, may have implications for the understanding of genetic events associated with disease progression in this pathology.

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