Background: People with schizophrenia continue to suffer from negative functional outcomes and long-term morbidity despite a legacy of empirical research and development of several types of treatments Negative symptoms and low self-esteem in schizophrenia account for much of the poor ability to cope with every day activities and consequently the quality of life of the person with schizophrenia. Applying mindful self-compassion intervention (MSC) may decrease the negative symptoms and improve the patient self-esteem. Objective: Evaluate the impact of mindful-self compassion intervention on self-esteem and negative symptoms in patients with schizophrenia Settings: The present study was carried out in the inpatient wards of El-Maamoura Hospital for Psychiatric Medicine in Alexandria. Subjects:68 patients with schizophrenia. Tools: four tools were used for data collection. The first tool A Socio-demographic and clinical data collection tool: This tool was developed by the researcher. The second tool was self-compassion scale to assess the degree of self-compassion of patients with schizophrenia. The third tool was Rosenberg self-esteem scale to assess the degree of self-esteem. The fourth tool was Scale for Assessment of Negative Symptoms ( SANS) to assesses the negative symptoms of patients with schizophrenia Results: Findings of the present study revealed that the improvement of self-compassion percentage of the patients who had high self-esteem pre-intervention (8.8%)was increased in post intervention to (64.7%) Conclusion: mindful self-compassion (MSC) can successful in decreasing the severity of overall negative symptoms of patients with schizophrenia and improve their self-esteem and their self-compassion.. Recommendations: Psychiatric hospitals may support the application of mindful self-compassion intervention as an integral component in the hospital routine care and rehabilitation program for patients with schizophrenia