Alopecia areata (AA) is a common form of autoimmune nonscarring hair loss of scalp and/or body. Atypical hair regrowth in AA is considered a rare phenomenon. It includes atypical pattern of hair growth (sudden graying, perinevoid alopecia, Renbok phenomenon, castling phenomenon, and concentric or targetoid regrowth) and atypical dark color hair regrowth. We report a case of AA that resulted in a concentric targetoid hair regrowth and discuss the possible related theories regarding the significance of this phenomenon.

Advances in knowledge of neurocellulars relations have provided new directions in the understanding and treatment of numerous conditions, including atopic dermatitis. It is known that emotional, physical, chemical or biological stimuli can generate more accentuated responses in atopic patients than in non-atopic individuals; however, the complex network of control covered by these influences, especially by neuropeptides and neurotrophins, and their genetic relations, still keep secrets to be revealed. Itching and airway hyperresponsiveness, the main aspects of atopy, are associated with disruption of the neurosensory network activity. Increased epidermal innervation and production of neurotrophins, neuropeptides, cytokines and proteases, in addition to their relations with the sensory receptors in an epidermis with poor lipid mantle, are the aspects currently covered for understanding atopic dermatitis.

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Stiff skin syndrome is a rare scleroderma-like disorder of unknown etiology characterized by stone-hard indurations of skin, mild hypertrichosis and limited joint mobility. No effective treatment has yet been found. Exercises and rehabilitative therapy are important in maintaining the patient's quality of life. The authors present a case of a two-year-old boy with progressive skin hardening since he was eightmonth old and secondary restricted joint mobility, diagnosed as Stiff skin syndrome. Keywords: Contracture; Fascia; Mucopolysaccharidoses; Rare diseases; Scleroderma, systemic Resumo: Síndrome stiff skin é doença rara, esclerodermiforme, de etiologia desconhecida, caracterizada por endurecimento pétreo da pele, hipertricose leve e limitação da mobilidade articular. Não há tratamento efetivo até o momento. Exercícios e reabilitação são importantes para manter a qualidade de vida do paciente. Os autores apresentam caso de um menino de dois anos de idade com endurecimento cutâneo progressivo desde os oito meses de idade e restrição secundária da mobilidade articular, diagnosticado como Síndrome stiff skin.

RESUMO -Queratodermia marginada palmar é caracterizada pela queratodermia em faixa, nos limites das partes dorsal e palmar, em disposição nas bordas cubital e radial em pacientes com intensa exposição solar. De acordo com a literatura, por si só, a queratodermia marginada palmar não é considerada uma lesão pré-maligna. Relatamos o primeiro caso de carcinoma de células escamosas ou carcinoma espinocelular sobre queratodermia marginada palmar em uma mulher de 57 anos. PALAVRAS-CHAVE -Carcinoma de Células Escamosas; Mão; Neoplasias da Pele Queratodermia Palmar e Plantar. Squamous Cell Carcinoma on Marginal Palmar Keratoderma ABSTRACT -Marginal palmar keratoderma is characterized by palmar keratoderma affecting the limits of the dorsal and palmar regions of ulnar and radial edges in patients with