Systemic lupus erythematosus is a rare autoimmune disease. It leads to an increased production of proinflammatory molecules that accelerates atherogenesis and could cause an endothelium dysfunction. The aim of the study was to assess cardiovascular risk factors such as BMI and lipid profile as well as left ventricular ejection fraction among patients with SLE, and a correlation of these factors with duration of the disease. Materials and Methods. The researched group consisted of patients with SLE, being under control of the outpatient clinic of cardiology. This group included 38 patients among whom 34 were women (56.17 ± 11.05 years) and 4 were men (65.50 ± 9.22 years). The control group consisted of 19 healthy women (53.31 ± 11.94 years) and 2 healthy men (38.51 ± 7.53 years). Measurements were taken in the same conditions by trained medical staff. Results. Excessive body weight (BMI >25 kg/m2) was more frequent in the SLE group, but it was not statistically significant (55.26% vs. 52.38%, p = 0.6159 ). LVEF values were lower in their searched group, and this factor showed statistical significance (53.92% ± 6.46 vs. 58.67% ± 4.69, p = 0.0044 ). Thickness of the IMT was higher and statistically important among patients with SLE, both in left (1.22 ± 0.27 mm vs. 0.7 ± 0.21 mm, p = 0.0001 ) and right common carotid artery (1.16 ± 0.26 mm vs. 0.59 ± 0.15 mm, p = 0.0001 ), compared to the controls. Conclusions. Patients with SLE are at greater risk of developing cardiovascular diseases as the illness progresses. The activity of the disease according to the SLEDAI-2K scale may have an impact on the LVEF values which was significantly decreased in the group with active disease, but further thorough investigation is required to fully evaluate the impact of individual components of the disease and its treatment on the CVD development and mortality.

Introduction: Systemic lupus erythematosus is an autoimmune disease characterized by the production of antinuclear and cytoplasmic antibodies that can affect many organs. Cardiovascular diseases occurring in patients with SLE include myocardial infarction, coronary heart disease, stroke, transient cerebral ischemia, or thromboembolic disorders.Early identification of heart dysfunction in SLE is important in determining the course of the disease. Aim of the study:The aim of this study was to show the relationship between the presence of SLE and changes in echocardiographic parameters, in particular LVEF, 6MWT results and complete blood count. We also aimed to show the correlation between disease duration and LVEF. Material and methods:The subjects of this study were patients with SLE. The study results from October 2014 to February 2019 were analyzed. The analysis included 45 patients with SLE, comprising 40 women aged 55.67 ± 11.34 years and 5 men aged 62.6 ± 8.43 years. The study group consisted of patients with an SLE diagnosis and an average disease duration of 12.58 ± 8.18 years. Results:In the echocardiographic study, the left ventricular end-diastolic diameter in the parasternal long-axis view was significantly larger in the SLE group than in the non-SLE group (45.60 ± 6.72 vs. 40.75 ± 6.83 mm, p = 0.0247).In the 6MWT, the distance covered by the SLE group was statistically smaller than that of the non-SLE group (547.86

No abstract