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At the hospital, the pharmacist is constantly challenged to prepare extemporaneous solutions from tablets, capsules or drug powder for patients unable to swallow, such as pediatric, elderly and patients that use nasoenteric and nasogastric tubes. The preparation of extemporaneous solutions from capsules, tablets and drug powder requires stability studies analysis. This article is a bibliographic review of preparation of extemporaneous oral liquid from solid oral dosage forms used in clinical practice. The selected articles contain all the information regarding manipulation techniques, pharmaceutical excipients, packaging, storage conditions and results of stability studies above 90% performed by HPLC analysis. In addition, a situational analysis of the strategies for the preparation of the extemporaneous solution was described to help the manipulator in the decision. The preparation of extemporaneous solution from solid oral dosage forms is based on information from official compendium or scientific literature, to ensure safe and effective manipulated medicine.

In the present study, an inclusion complex composed of hydrocortisone acetate (HA) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) was prepared according phases solubility diagram of Higuchi & Connors and by a method described by with minor modifications to improve the HA water solubility. This new method improved percentage of inclusion reaching the maximum percentage of inclusion (91.52±0.92%) using 5.75mM HA and 135mM HPβCD. This percentage of inclusion was higher than that found by Filipović-Grcić J et al.[1] which was 25%. The complex HA/HPβCD was characterized by 1 H-NMR through chemical shifts in 1 H NMR spectra after the inclusion of HA into the HPβCD cavity, especially H-3, H-5 and H-6 protons was observed to the formation of molecular inclusion complex. Other technique used to characterize the inclusion complex was FT-IR, which showed in the FT-IR spectra of inclusion complex no features bands similar to pure HA molecule; the spectrum is very similar to the HPβCD. The molecular modeling studies results are in agreement with the experimental data that estimates a HA/HPβCD molar ratio of 1:1. The calculated apparent stability constant (K S ) was 484 M -1. The results indicate that the HA/HPβCD inclusion complex is more water soluble than HA crystalline powder (pure), the AH solubility was increased on the order of 64 times.