The objective of the present study was to compare cardiovascular and autonomic responses to a mental stress test and to a maximal isometric exercise test between offspring of normotensive (ON, n = 10) and hypertensive parents (OH, n = 10). Subjects underwent a 3-min Stroop Color Word Test and a maximal isometric exercise test performed in an isokinetic dynamometer with continuous RR interval monitoring. At rest, arterial pressure and heart rate were similar between groups, but there was a significant reduction in total RR interval variance (ON: 5933 ± 493 vs. OH: 2967 ± 390 ms(2)) and an increase in low-high frequency components ratio of heart rate variability (ON: 2.3 ± 0.4 vs. OH: 4.6 ± 0.8) in OH group. In the first minute of the mental stress test and after both tests, the OH group presented increased heart rate as compared with the ON group. After both tests, only the ON group presented an increase in sympathetic component, thus reaching resting values similar to those of the OH group. Our data demonstrated increased resting cardiac sympathetic modulation in offspring of hypertensive parents at similar levels to that observed in offspring of normotensive parents after a mental stress test or a maximal isometric exercise test. Additionally, the exacerbated heart rate responses to these physiological tests in OH subjects may be associated with resting autonomic dysfunction, thus reinforcing these evaluations as important tools for detecting early dysfunctions in this genetically predisposed population.

Objetivo: O presente estudo caracterizou o perfil metabólico e a terapêutica medicamentosa de 50 pacientes com síndrome metabólica. Métodos: Foram coletadas dos prontuários dos pacientes os dados de exames de perfil lipídico e glicêmico, perfil antropométrico, pressão arterial e informações sobre a terapêutica medicamentosa. Resultados: Os pacientes apresentaram média de idade de 65±9 anos, com 33,3% tendo concluído até no máximo o ensino fundamental. Em relação ao estilo de vida, 32% eram fumantes ou ex-fumantes, 54% sedentários e 83% apresentavam sobrepeso ou obesidade. Sobre a pressão arterial, 90% apresentaram hipertensão. Dos hipertensos, 53% não se encontravam nas metas terapêuticas e, 33% acima dos valores de controle sugeridos pelas diretrizes. No que se refere ao perfil lipídico, 56% dos pacientes não estavam na meta terapêutica estabelecida para as triglicérides, assim como 50% dos homens e 53% das mulheres não estavam para os valores sugeridos de HDL. Em relação à glicemia, 70,2% apresentavam diabetes e destes, 58% estavam com glicemia acima do estabelecido como meta terapêutica valores acima do recomendável. Conclusão: Conclui-se que os pacientes não se encontravam nas metas terapêuticas e devem receber melhor acompanhamento dos profissionais de saúde a fim de evitar os danos cardiovasculares.

The aim of this study was to verify the effects of one aerobic exercise session (AES) on the metabolic and hemodynamic profile in diabetes type II offspring. Healthy young males were assigned into 2 groups: diabetic offspring (DO, n=7) and euglycemic offspring (EO, n=7). Metabolic (triglycerides and glucose levels) and cardiovascular (arterial pressure, AP, heart rate, HR) measures were realized before, during and after the AES. The AES was realized on a treadmill during 30 minutes, with progressive intensity. The groups showed similar triglycerides, AP and HR values at rest. The glucose level was higher in DO group when compared to the ED group (99±2 vs. 89±2 mg/dL). The DO group showed higher chronotropic response at the beginning of AES when compared to the EO group (86±4 vs. 125±8 bpm), however, the HR was similar between the groups at the other exercise intensities. At the fifth minute of the recovery, the HR was higher in the DO group when compared to the EO group (FN: 88 ± 3 vs FD: 97± 4 bpm). The AP was similar between groups during and after the AES. The results showed that young diabetic offspring presented metabolic alterations at rest, and exacerbated HR response at the beginning and in the recovery period of the AES, suggesting a higher cardiovascular risk in this population.