The main objective of this study was to evaluate the antioxidant capacity and possible toxicological potential of the infusions prepared from Ibervillea sonorae. For this, infusions were prepared from the root of I. sonorae, using the skin or the pulp. The antioxidant capacity of the infusions was evaluated through the ABTS and DPPH tests. While, the Artemia salina model, the MTT test using Vero and MCF-7 cells, and the Ames test were used to evaluate the possible toxicological potential. The results showed that I. sonorae peels were more lethal (60-80%) than pulp (<50%). Interestingly, I. sonorae pulp showed greater toxicity on Vero cells (IC50 = 222 µg / mL) than infusions made using the skins (IC50 = 379 µg / mL). Infusions of I. sonorae, either in the form of peel or pulp, showed high mutagenicity at 1000 and 500 µg/mL. The ingestion of infusions prepared from the I. sonorae plant could cause serious damage to health. DOI: https://doi.org/10.54167/tecnociencia.v16i2.903