The plastic industry has recognized that mixture of polymers, called polymeric blends, yields new materials with improve properties and better features of those of the polymer blended. In most of the cases, blends are formed by immiscible components presenting separated phases, micro-structures or morphologies. One of the main factors for good mechanical performance is the interfacial adhesion of the blend components. The improvement of miscibility between the polymer components and the enhancement of blend performance is denominated of compatibilization. This compatibilization can be achieved by chemical methods or using ionizing radiation. The present work has as a main objective the study of the effect of the ionizing radiation from electron beam in the compatibilization of the polyamide (PA) 6.6 and low density polyethylene (LDPE) 75%/25% wt blend, in the range of applied doses from 50 to 250 kGy. The compatibilization effect was evaluated by mechanical test, which has shown improvement in the tensile strength and hardness properties and a reduction of the impact resistant. This mechanical behavior can be considered as a combination effect of the cross-linking, induced in the molecular structure on the polymers, and the increase of the miscibility of the blend components. The degree of compatibilization was evaluated by the behavior of the glass transition temperatures (T g) for the blend components obtained by dynamic mechanical analysis (DMA) measurements. The results have shown that the values of T g for PA 6.6 and LDPE get near by 8 o C, showing that the ionizing radiation have promoted a compatibilization effect on the irradiated blend.