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Down syndrome (DS) is the most common genetic cause of learning difficulties and intellectual disabilities. DS patients often present with several congenital defects and chronic diseases, including immunity disorders. Elevated levels of pro-inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) have been seen, which appear to vary with age. At birth, patients present with combined immunodeficiency, with frequent infections that decrease with age. Furthermore, high levels of IL-4 and IL-10 with anti-inflammatory properties and low levels of IL-6 and TNF-α are described in children. The immune system is believed to play an essential role in SARS-CoV-2 pathogenesis, and it has been associated with elevated levels of pro-inflammatory cytokines and an exaggerated cytokine release syndrome (CRS) that may eventually trigger a severe situation called cytokine storm. On the other hand, genetic features seem to be involved in the predisposition to illness and its severity. Overexpression of DSCR1 and ZAKI-4 inhibits the translocation of activated T lymphocyte nuclear factor (NF-AT) to the nucleus, a main step in the inflammatory responsiveness. We discuss here the possible role of immunology and genetic features of DS in the infection and prognosis in COVID-19.

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The worldwide population prevalence of autism is about 1%. The current panorama that we are experiencing with the COVID-19 pandemic, makes it difficult for many people to understand and assimilate everything what is happening. In persons with autism, this difficulty can become extreme, both in children and adults. However, there are some recommendations to help process and assimilate this situation and like this avoid or reduce complications in this population. This recommendations are simple, but they are difficult to perform. However, they can help keep the loved ones and their family members more bearable. Only by knowing its characteristics and applying a few recommendations or guidelines, caregivers and the affected persons will be able to lead a more enjoyable life.

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