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) lowered the hemorrha gic activity of the venom alone in CD1 mice by 51.5 ± 2.6 %. Additionally, 1.7 mg extract L -1 plasma prolonged 5.1 times the plasma coagulation time. Fractionation of the extract led to the isolation of two compounds: ononitol (1) and quercetrin (2). The structure of compounds 1 and 2 was esta blished by spectroscopic analyses, including APCIHR MS and NMR ( 1 H, 13 C, HSQC, HMBC and COSY). A quercetrin concentration of 0.11 mmol L -1 prolonged the plasma coagulation time 2.6 times demonstrating that this compound was one of the active constituents of the Brownea rosademonte extract.

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the effectiveness and safety of the eye drops in a premature infant. Material and methods Case description: a premature infant (26 weeks' gestation) was diagnosed with conjunctivitis due to Stenotrophomonas maltofilia multi-resistant, sensitive to levofloxacin. The neonatal intensive care unit requested the manufacture of levofloxacin based eye drops. The pharmacy service initiated a bibliographic search to find out the indication, dosage, manufacture and stability of levofloxacin 0.05% based eye drops. Results We decided to prepare it with injectable levofloxacin 500 mg/100 mL, taking into account the physical and chemical characteristics an ophthalmic drug should have:. non-contraindicated excipients (injectable excipients: water, HCl and NaOH);. acceptable pH (4.4-5.5) and osmotic concentration (300-310 mOsm/l).