Rationale: Speed of heart rate recovery (HRR) may serve as an important biomarker of aging and mortality. Objective: To examine whether the speed of HRR after an orthostatic maneuver (ie, active stand from supine position) predicts mortality.
Methods and Results:A longitudinal cohort study involving a nationally representative sample of communitydwelling older individuals aged ≥50 years. A total of 4475 participants completed an active stand at baseline as part of a detailed clinic-based cardiovascular assessment. Beat-to-beat heart rate and blood pressure responses to standing were measured during a 2-minute window using a finometer and binned in 10-s intervals. We modeled HRR to the stand by age group, cardiovascular disease burden, and mortality status using a random effects model.
Mortality status during a mean follow-up duration of 4.3 years served as the primary end point (n=138). Speed of HRR in the immediate
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