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Objective-To determine the risk of rare complications during pregnancy for women with systemic lupus erythematosus (SLE).Study Design-Using the Nationwide Inpatient Sample from 2000 to 2003, we compared maternal and pregnancy complications for all pregnancy-related admissions for women with and without SLE.Results-Out of over 16.7 million admissions for childbirth over the 4 years, 13,555 were to women with SLE. Maternal mortality was 20-fold higher among women with SLE. The risks for thrombosis, infection, thrombocytopenia, and transfusion were each 3-7-fold higher for women with SLE. Lupus patients also had a higher risk for cesarean sections (OR 1.7), preterm labor (OR 2.4), and preeclampsia (OR 3.0) than other women. Women with SLE were more likely to have other medical conditions, including diabetes, hypertension, and thrombophilia, that are associated with adverse pregnancy outcomes.Conclusions-Women with SLE are at increased risk for serious medical and pregnancy complications during pregnancy.

Background-The purpose of this study was to determine the incidence, mortality, and risk factors for pregnancy-related acute myocardial infarction in the United States. Methods and Results-The

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