Recent studies have found that oxygen saturation (SpO 2 ) variability analysis has potential for noninvasive assessment of the functional connectivity of cardiorespiratory control systems during hypoxia. Patients with sepsis have suboptimal tissue oxygenation and impaired organ system connectivity. Our objective with this report was to highlight the potential use for SpO 2 variability analysis in predicting intensive care survival in patients with sepsis. MIMIC-III clinical data of 164 adults meeting Sepsis-3 criteria and with 30 min of SpO 2 and respiratory rate data were analyzed. The complexity of SpO 2 signals was measured through AUTHORS' CONTRIBUTION Ali R. Mani, Watjana Lilaonitkul, and Margaret Gheorghita conceived the study and formulated the concept of oxygen saturation variability analysis in sepsis.