Although the clearance of endogenous creatinine as a measure of the glomerular filtration rate has been much criticized, it remains the only possible measure where repeated or continuous investigation is needed, and has already yielded much useful information. When we started to use it, however, it became apparent that while the estimation of creatinine in urine was satisfactory, that of plasma creatinine was not. The purpose of this work was therefore to establish a standard method of estimation simple enough for routine use. When this had been evolved it was used for a series of creatinine clearances, which were compared with simultaneous inulin clearances to see whether a reasonable agreement was apparent.

IT has already been recorded that the fresh egg-white of the hen's egg contains vitamin B2 unaccompanied by the antineuritic vitamin B1 [Chick and Roscoe, 1929, 1]. In this property egg-white stands alone amongst the foodstuffs hitherto examined, for in all others in which vitamin B2 has been found, vitamin B has also been present, although the relative amounts of the two have shown a wide variation [Aykroyd and Roscoe, 1929;Roscoe, 1930].This unusual property makes egg-white a valuable material for use in the investigation of the various members of the B group of vitamins. It has, therefore, seemed worth while to publish a short account of the evidence upon which the above statement is based.Vitamin B1 deficiency of egg-white. If young rats immediately after weaning receive an artificial diet deprived of vitamin B1, but otherwise complete and containing egg-white as source of protein and of vitamin B2 [see Chick and Copping, 1930, 3, p. 1765, Diet II], growth takes place for 2-3 weeks, after which appetite fails and a decline in weight sets in. If this is not checked death will often follow and will be preceded by the paralysis characteristic of vitamin B1 deficiency, which is promptly cured if vitamin B1 is given. If, at the point where weight has become stationary or has begun to decline, vitamin B1 is given as a daily dose of some foodstuff containing it, or as Peters's antineuritic concentrate, growth is immediately restored and the gain in weight will be in relation to the amount of vitamin B1 administered. These facts have been applied in a method for estimation of vitamin B1 in foodstuffs [Chick and Roscoe, 1929, 1].Vitamin B2 content of egg-white. The content of vitamin B2 can be estimated by measuring the minimal daily dose required to restore growth which has ceased in young rats after short periods, 1-2 weeks, on a synthetic diet containing vitamin B1 and lacking only vitamin B2 [Chick and Roscoe, 1928]. It has been found that a daily dose of 2-5-5-0 g. of fresh, cooked, egg-white (dry weight 0-3-0-6 g.) or of an

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BREAD made from wheaten flour and yeast is one of the most widely distributed forms of food. With the possible exception of rice and maize it enters into the diet of more people than does any other single foodstuff, and in many cases, owing to its cheapness and high calorie value, it is the chief constituent of the diet. This being so, it is natural that the question of its nutritive value should be a matter of importance. Whole cereals contain fairly considerable amounts of the B-vitamins, but as the germ and pericarp are relatively richer than the endosperm, and these are removed in milling, a great part of the vitamin value of cereals is lost. A high proportion of cereal products, poor in B-vitamins, may normally be supplemented by other foodstuffs in a varied diet, but in times of economic stringency, when satisfaction of the calorie requirements is the first consideration, these supple

The Preceding paper by Fridericia and his co-workers on “A Transmissible Change in the Instestinal Content, enabling Rats to Grow and Thrive without vitamin B in the Food” deals with results so novel and unexpected that a brief statement from another laboratory confirming them, is not redundant.