This study aimed at evaluating the therapeutic effects of ethanolic extract of Polygonum limbatum meism (EEPLM) on the reproductive parameters of male Guinea pigs exposed to cadmium chloride. Thirty-six male guinea pigs were randomly assigned to six treatment groups (with six animals per group). Group 1 (DW) received distilled water orally; group 2 (Cd), negative control, was treated with cadmium chloride at a dose of 26.25 mg/kg body weight (bw); while group 3 (VitC), positive control, was given 26.25 mg of cadmium chloride/kg bw and 100 mg of vitamin C, and groups 4, 5, and 6 were treated, respectively, with EEPLM at doses of 50, 100, and 200 mg/kg bw in addition to cadmium chloride (26.25 mg/kg bw). After 90 days, all animals were sacrificed, and data related to reproduction, toxicity, and oxidative stress were collected. Results revealed a significant decrease (p < 0.05) of serum levels of creatinine, urea, alanine, and aspartate amino transferases in guinea pigs treated with cadmium chloride and EEPLM compared to the negative control group (Cd). The weight of the bulbo-urethral gland was significantly (p < 0.05) decreased in animals exposed to cadmium chloride and treated with vitamin C or EEPLM compared to the negative control (Cd). Guinea pigs orally receiving cadmium chloride and EEPLM showed significantly (p < 0.05) increased motility, sperm count, spermatozoa with entire plasma membrane, and percentage of normal spermatozoa with reference to the negative control (Cd). The serum level of testosterone increased insignificantly (p > 0.05) in animals given cadmium and EEPLM compared to the negative control (Cd). Animals co-administered cadmium chloride and EEPLM recorded a significantly (p < 0.05) reduced level of MDA, activities of SOD, and total peroxidases compared to the group that received cadmium chloride (Cd) only. In conclusion, cadmium chloride induced reproductive impairments by generating oxidative stress. However, the administration of EEPLM can mitigate these adverse effects due to its antioxidant properties.

The present study was assigned to evaluate the Effect of Dracaena arborea roots powder in ration on growth performances and some hematological parameters in the guinea pig on diet supplemented with graded levels of incorporation. A total of 40 guinea pigs weaned of local breed and aged 3 weeks were divided into 4 identical batches. Each of the groups was randomly assigned one of 4 rations containing different levels of the powder from Dracaena arborea (Da) roots: Da0; Da0.25; Da0.5 and Da0.75. The results at the 11th week of breeding showed that the highest intake (21.13 g/d) was obtained with the Da0.5 ration. The highest live weight (372.50 g) and total weight gains were obtained with the Da0.25 ration. In addition, the highest commercial (161.75 g) and conventional (307.75 g) carcass weights and large intestine length (99.5 cm) were obtained with the D0.25 ration. The highest values for granulocytes (0.250.10 3 /µl), platelets (805.10 3 /µl) and lymphocytes (6.92.10 3 /µl) were respectively, obtained with the rations containing Da0; D0.5 and D0.75. In view of the above, Dracaena arborea roots powder can be used at a rate of 0.25% in the ration, to improve the productivity of the guinea pig (Cavia porcellus).

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