This article examines children's spatial mobility in urban settings. Through data from a study of children living in contrasting urban environments, London and a lower-density new town, the article focuses on how children move around in the public realm. The data show that there are significant variations in how contemporary children use their public spaces. Children's freedom to move around their neighbourhood was greatest in the new town. Girls and minority ethnic children were more restricted in their use of urban space. Comparison with previous research suggests a decrease in independent use of public space for 10/11-year-old English children since the 1970s. It is argued that future debate about children's place in the city should move away from `the unitary public child'. Lack of attention to the different ways children use their cities will hinder advances in social policies designed to enhance participation for all children.

Infant care is no longer purely a private family matter. As more mothers return to paid employment in their child's first year, governments develop provisions to support working parents with very young children. Statutory parental leave and flexible working provisions for fathers are expanding rapidly, particularly in Europe. The author compares fathers' patterns of leave-taking across twenty-four countries from 2003 to 2007 to present new types of father-care-sensitive leave models. Findings show that fathers' use of statutory leave is greatest when high income replacement (50 percent or more of earnings) is combined with extended duration (more than fourteen days). Father-targeted schemes heighten usage. Although studies are limited, parental leave has the potential to boost fathers' emotional investment in and connection with infants. Differential access to statuary leave raises the possibility of a new polarization for infants: being born into either a parental-leave-rich or -poor household and, indeed, country

The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623).

Pre-eclampsia is a disorder of human pregnancy occurring in 5-10% of all births, and represents the leading cause of infant morbidity and mortality and maternal death. In pre-eclampsia, invasion of fetal trophoblasts into maternal arteries during early pregnancy is shallow or absent. Here we examined the hypothesis that HLA-G, a non-classical class I HLA expressed in cytotrophoblasts, may act as a key gene in pre-eclampsia. We analysed HLA-G at the level of transcription and genotyped a silent CAC-CAT polymorphism in exon 3 and a 14-bp insertion/deletion in the 3' untranslated region. A deficit in levels of the HLA-G3 transcript was observed in mild pre-eclampsia compared to normal placentas. The distribution of HLA-G polymorphisms was different between normal and pre-eclampsia samples. A correlation between the alteration in transcription of the HLA-G gene and certain HLA-G genotypes was also observed. Thus we provide the first evidence for a possible role of HLA-G in genetic susceptibility to, and pathogenesis of pre-eclampsia.

SUMMARYBackground: While wintertime vitamin D deficiency has been well-documented in Crohn's disease patients, less is known about vitamin D status during summertime and whether a seasonal variation exists in bone turnover. Aims: To compare vitamin D status and bone turnover markers in Crohn's disease patients with ageand sex-matched controls during late-summer and late-winter. Subjects: Crohn's disease patients (n ¼ 44; mean age 36.9 years, currently in remission) and matched controls (n ¼ 44) were recruited from Cork University Hospital and Cork City area, respectively. Methods: Bloods were analysed for 25-hydroxyvitamin D, parathyroid hormone, bone-specific alkaline